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Pathophysiological Aspects of Proteases pp 535–551Cite as

Role of Proteases in Regulating Cell Death Pathways

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Abstract

Cell death is a critical process involved during development, tissue homeostasis, and aging. Multiple forms of cell death exist such as apoptosis (type I cell death), necrosis, and autophagy (type II cell death). Recently, other selective forms of cell death such as pyroptosis, eryptosis, entosis, mitophagy, and oncosis are also reported. These cell death pathways collaborate with each other, and regulation of such mechanisms is crucial for maintaining cellular homeostasis. Interestingly, proteases are the one that mediate the cell death programs, and immense research is focused on elucidating the mechanisms through which protease regulates cell death program. In this chapter, we focus on various cell death pathways and how protease regulates these pathways.

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Acknowledgement

The authors thank the support of University Grants Commission (UGC)-UPE Phase II for carrying out a part of work in calcium signaling.

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Authors and Affiliations

  1. Cell Biology Laboratory, Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India

    Thomas Divya, Sekar Vasudevan & Ganapasam Sudhandiran

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  1. Thomas Divya
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  2. Sekar Vasudevan
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  3. Ganapasam Sudhandiran
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Correspondence to Ganapasam Sudhandiran .

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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Institute of Cardiovascular Sciences, University of Manitoba, Manitoba, Canada

    Naranjan S. Dhalla

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Divya, T., Vasudevan, S., Sudhandiran, G. (2017). Role of Proteases in Regulating Cell Death Pathways. In: Chakraborti, S., Dhalla, N. (eds) Pathophysiological Aspects of Proteases. Springer, Singapore. https://doi.org/10.1007/978-981-10-6141-7_21

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