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Molecular Virology and Life Cycle

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Hepatitis B Virus and Liver Disease

Abstract

The hepatitis B virus is a prevalent human infection with no cure at present. It is a significant cause of global morbidity and mortality and has achieved its persistence in humans via its complex life cycle and ability to use its few protein products in a multifunctional manner to subvert and evade immune detection and clearance. These aspects of the virus are discussed in detail, as are the development of clinically important mutations in the viral genome that develop as a result of host immune selection, as well as those selected by the introduction of antiviral therapy or vaccination.

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Authors and Affiliations

  1. Department of Gastroenterology, St. Vincent’s Hospital, Melbourne, Fitzroy, VIC, 3065, Australia

    Darren J. Wong

  2. Department of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, Melbourne, VIC, 3000, Australia

    Stephen A. Locarnini

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  1. Darren J. Wong
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  2. Stephen A. Locarnini
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Correspondence to Stephen A. Locarnini .

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  1. Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan

    Jia-Horng Kao

  2. Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Genomics Research CenterAcademia Sinica, Taipei, Taiwan

    Ding-Shinn Chen

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Wong, D.J., Locarnini, S.A. (2018). Molecular Virology and Life Cycle. In: Kao, JH., Chen, DS. (eds) Hepatitis B Virus and Liver Disease. Springer, Singapore. https://doi.org/10.1007/978-981-10-4843-2_1

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