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Imaging: US and CT

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IgG4-Related Sclerosing Cholangitis

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Abstract

IgG4-related disease (IgG4-RD) is characterized by increased serum levels of IgG4, a lymphoplasmacytic infiltrate composed of IgG4-positive plasma cells, storiform fibrosis, obliterative phlebitis, and mild to moderate eosinophilia [1]. IgG4-related sclerosing cholangitis (IgG4-SC) is a biliary lesion associated with IgG4-RD, which is frequently seen in elderly men, characterized by obstructive jaundice owing to a bile duct stricture and responds well to steroid therapy [2]. Recently, the first clinical diagnostic criteria for IgG4-SC were proposed in Japan [3]. As in the diagnostic items of the 2012 IgG4-SC diagnostic criteria, biliary tract imaging of IgG4-SC reveals diffuse or segmental narrowing of the intrahepatic and/or extrahepatic bile duct associated with thickening of the bile duct wall [3].

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Author information

Authors and Affiliations

  1. Igarashi Medical Clinic, Fukuoka, Japan

    Hisato Igarashi

  2. Neuroendocrine Tumor Centre, Fukuoka Sanno Hospital, International University of Health and Welfare, Fukuoka, Japan

    Testuhide Ito & Masayuki Hijioka

  3. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Kosei Ishigami

  4. Department of Community-Based Medical Education, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan

    Hirotaka Ohara

Authors
  1. Hisato Igarashi
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  2. Testuhide Ito
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  3. Kosei Ishigami
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  4. Masayuki Hijioka
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  5. Hirotaka Ohara
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Corresponding author

Correspondence to Testuhide Ito .

Editor information

Editors and Affiliations

  1. Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Bunkyo-ku, Tokyo, Japan

    Terumi Kamisawa

  2. Department of Internal Medicine, ASAN Medical Center, Seoul, Korea (Republic of)

    Myung-Hwan Kim

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Igarashi, H., Ito, T., Ishigami, K., Hijioka, M., Ohara, H. (2019). Imaging: US and CT. In: Kamisawa, T., Kim, MH. (eds) IgG4-Related Sclerosing Cholangitis. Springer, Singapore. https://doi.org/10.1007/978-981-10-4548-6_8

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  • DOI: https://doi.org/10.1007/978-981-10-4548-6_8

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-4547-9

  • Online ISBN: 978-981-10-4548-6

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