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Treatment Resistance in Bipolar Disorders

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Treatment Resistance in Psychiatry

Abstract

Bipolar disorder (BD) is among the most prevalent and incapacitating severe mental illnesses. Although the rates of resistance to treatment among bipolar patients are not known, literature findings suggest that partial or no response to conventional agents seems to be extremely common. The present chapter addresses the different issues involved in the phenomena of treatment resistance among bipolar patients. It begins with a discussion of the challenges surrounding the concept of resistant BD, followed by some discussion regarding the possible pathophysiological factors involved in the development of resistance. Next, possible therapeutic interventions aiming at the management of treatment-resistant patients are addressed, including the potential role of novel pharmacological agents, neurostimulation, and psychosocial interventions.

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Authors and Affiliations

  1. Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA

    Marsal Sanches, João Quevedo & Jair C. Soares

  2. Department of Psychiatry and Behavioral Sciences, University of North Dakota School of Medicine, Grand Forks, ND, USA

    Marsal Sanches

  3. Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA

    João Quevedo

  4. Neuroscience Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA

    João Quevedo

  5. Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil

    João Quevedo

Authors
  1. Marsal Sanches
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  2. João Quevedo
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  3. Jair C. Soares
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Editors and Affiliations

  1. Department of Psychiatry, College of Medicine, Korea University, Seoul, Korea (Republic of)

    Yong-Ku Kim

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Sanches, M., Quevedo, J., Soares, J.C. (2019). Treatment Resistance in Bipolar Disorders. In: Kim, YK. (eds) Treatment Resistance in Psychiatry. Springer, Singapore. https://doi.org/10.1007/978-981-10-4358-1_9

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  • DOI: https://doi.org/10.1007/978-981-10-4358-1_9

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  • Online ISBN: 978-981-10-4358-1

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