Abstract
In this paper, we study computationally a mathematical model of post-traumatic stress disorder (PTSD). The PTSD is a common symptom resulted from a trauma or a long period of intense stress which leads to abnormal levels of hormonal secretion, especially in Cortisol. As a consequence, the neuronal electric activities also change due to variations in synaptic receptors regulated by hormone levels. We measure the hippocampal plasticity variability computationally through the synaptic spike-timing–dependent plasticity characterized in soma’s calcium current in the neuronal system, and the results provide the evidence of long-term potentiation changes in a Hippocampus model due to PTSD.
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References
American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th edn. American Psychiatric Association, Washington, DC (1994)
Helzer, J.E., Robins, L.N., McEvoy, L.: Post-traumatic stress disorder in the general population. N. Engl. J. Med. 317, 1630–1634 (1987)
Sherin, J.E., Nemeroff, C.B.: Post-traumatic stress disorder: the neurobiological impact of psychological trauma. Dialogues Clin. Neurosci. 13(3), 263–278 (2011)
Kim, J.J., Song, E.Y., Kosten, T.A.: Stress effects in the hippocampus: synaptic plasticity and memory. Stress 9, 1–11 (2006)
McCarthy, J.: Post-traumatic stress disorder in people with learning disability. Adv. Psychiatr. Treat. 7, 163–169 (2001)
Bremner, J.D., Elzinga, B., Schmahl, C., Vermetten, E.: Structural and functional plasticity of the human brain in posttraumatic stress disorder. Prog. Brain Res. 167, 171–186 (2008)
Heresco-Levy, U., Javitt, D.C.: The role of N-Methyl-D-Aspartate (NMDA) receptor-mediated neurotransmission in the pathophysiology and therapeutics of psychiatric syndromes. Eur. Neuropsychopharmacol. 8, 141–152 (1998)
Javitt, D.C.: Glutamate as a therapeutic target in psychiatric disorders. Mol. Psychiatry 9, 984–997 (2004)
Reul, J.M., Nutt, D.J.: Glutamate and cortisol—a critical confluence in PTSD. J. Psychopharmacol. 22, 469–472 (2008)
Benita, J.M., Guillamon, A., Deco, G., Sanchez-Vives, M.V.: Synaptic depression and slow oscillatory activity in a biophysical network model of the cerebral cortex. Front Comput. Neurosci. 6, 64 (2012)
Rubin, J.E., Gerkin, R.C., Bi, G.Q., Chow, C.C.: Calcium time course as a signal for spike-timing–dependent plasticity. J. Neurophysiol. 93, 2600–2613 (2005)
Sriram, K., Rodriguez-Fernandez, M., Doyle, F.J.: Modeling Cortisol dynamics in the neuro-endocrine axis distinguishes normal, depression, and Post-traumatic Stress Disorder (PTSD) in humans. PLoS Comput. Biol. 8, e1002379 (2012)
Yehuda, R., Southwick, S., Krystal, J., Bremner, D., Charney, D., Mason, J.W.: Enhanced suppression of cortisol following dexamethasone administration in posttraumatic-stress-disorder. Am. J. Psychiatry 150, 83–86 (1993)
Yehuda, R., Teicher, M., Trestman, R., Levengood, R., Siever, L.: Cortisol regulation in posttraumatic stress disorder and major depression: A chronobiological analysis. Biol. Psychiatry 40, 79–88 (1996)
Gupta, S., Aslakson, E., Gurbaxani, B.M., Vernon, S.D.: Inclusion of the glucocorticoid receptor in a hypothalamic pituitary adrenal axis model reveals bistability. Theor. Biol. Med. Model 4, 8 (2007)
Vinther, F., Andersen, M., Ottesen, J.T.: The minimal model of the hypothalamic-pituitary adrenal axis. J. Math. Biol. 63, 663–690 (2011)
Poirazi, P., Brannon, T., Mel, B.W.: Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell. Neuron 37, 977–987 (2003)
Abbott, L.F., Nelson, S.B.: Synaptic plasticity: taming the beast. Nat. Neurosci. Suppl. 3, 1178–1183 (2000)
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Xiao, P., Duan, L., Su, J. (2016). The Synaptic Plasticity Variability in a Post-traumatic Stress Disorder Model. In: Wang, R., Pan, X. (eds) Advances in Cognitive Neurodynamics (V). Advances in Cognitive Neurodynamics. Springer, Singapore. https://doi.org/10.1007/978-981-10-0207-6_81
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DOI: https://doi.org/10.1007/978-981-10-0207-6_81
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