Abstract
Since the pioneer work of Metchnikoff it has become well established that a non-immunological inflammation can increase host resistance against infection1. However, little is known about the efffect of such an inflammatory process on anti-tumour defences. Fauve et al. 2 demonstrated that an inflammatory reaction induced in mice by injecting talc particles embedded in a calcium phosphate gel, delayed Lewis carcinoma growth and inhibited metastatic spreading. In the present work, the influence of an acute non-immunological inflammatory reaction induced by an intrapleural injection of an irritant on tumour growth and metastasis of three tumour models in rats and mice has been investigated.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Fauve, R. M. (1977). Inflammation and host resistance pathogen. Intensive Care Med., 3, 237
Fauve, R. M. and Hevin, M. B. (1977). Inflammation et résistance antitumorale. I. Retard de croissance et inhibition du developpement des métastases de la tumeur de Lewis chez des souris porteuses d’une réaction inflammatoire distante d’un site d’inoculation des cellules malignes. Ann. Immunol. (Paris) 128 C, 923
Willoughby, D. A., Dunn, C.J., Yamamoto, S., Capasso, F., Déporter, D. A. and Giroud, J. P. (1975). Calcium pyrophosphate induced pleurisy in rat: a new model of acute inflammation. Agents Actions, 5, 35
Van Den Brenk, H.A., Stone, M. and Kelly, H. (1974). Promotion of growth of tumor cells in acutely inflamed tissues. Br. J. Cancer, 30, 246
Giroud, J. P., Pelletier, M. and Girre, C. (1977). Pouvoir mitogene de serums de rats porteurs d’une inflammation aiguë vis à vis de macrophages en culture. C. R. Acad. Sci., Ser. D. 285, 1143
Pelletier, M. and Giroud, J. P. (1980). Effect of irradiation and cell reconstitution on the macrophage mitogenic activity of exudate and inflammatory serum. This volume, Chap. 121
Kiger, N., Pelletier, M., Florentin, I., Mathe, G. and Giroud, J. P. (1978). Effects of an non specific acute inflammatory stimulus on a macrophage and antibody dependent cellular cytotoxicity. Eur. J. Rheumatol. Inflam., 1, 321
Poste, G. (1979). The tumoricidal properties of inflammatory tissue macrophages and multinucleate giant cells. An. J. Pathol., 96, 595
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 MTP Press Limited
About this chapter
Cite this chapter
Nolibe, D., Florentin, I., Pelletier, M., Masse, R., Giroud, J.P. (1980). Effect of an acute inflammatory process on tumour development. In: Willoughby, D.A., Giroud, J.P. (eds) Inflammation: Mechanisms and Treatment. Inflammation: Mechanisms and Treatment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9423-8_98
Download citation
DOI: https://doi.org/10.1007/978-94-010-9423-8_98
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-9425-2
Online ISBN: 978-94-010-9423-8
eBook Packages: Springer Book Archive