Abstract
Ingestion of monosodium urate monohydrate (MSUM) crystals causes release of lysosomal and cytoplasmic enzymes from polymorphonuclear leukocytes1,2. These processes are well characterized and are believed to mediate many manifestations of acute gout3. In contrast, the mechanisms of tissue destruction in chronic gouty arthritis are poorly understood and there is little information about the interaction of MSUM with chronic inflammatory cells such as mononuclear phagocytes.
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McMillan, R. M:, Hasselbacher, P. and Harris, E. D., Jr. (unpublished data)
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McMillan, R.M., Hasselbacher, P., Harris, E.D. (1980). Monosodium urate monohydrate stimulates release of lysosomal enzymes and prostaglandins from macrophages. In: Willoughby, D.A., Giroud, J.P. (eds) Inflammation: Mechanisms and Treatment. Inflammation: Mechanisms and Treatment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9423-8_53
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DOI: https://doi.org/10.1007/978-94-010-9423-8_53
Publisher Name: Springer, Dordrecht
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