Abstract
Inhibition of prostaglandin (PG) synthesis contributes to the antiinflammatory activity of a number of anti-rheumatic compounds. Inhibition of PG synthesis by non-steroidal anti-inflammatory drugs (e.g. aspirin, indomethacin) has been observed in experiments with cell-free preparations of PG synthase as well as in intact tissues and cells1–3. These agents appear to act primarily by blocking the enzyme cylo-oxygenase which catalyses the initial step in synthesis of PGs from their fatty acid precursor, arachidonic acid4.
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McMillan, R.M., Brinckerhoff, C.E., Harris, E.D. (1980). Specificity of glucocorticoid inhibition of synovial prostaglandin synthesis. In: Willoughby, D.A., Giroud, J.P. (eds) Inflammation: Mechanisms and Treatment. Inflammation: Mechanisms and Treatment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9423-8_44
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DOI: https://doi.org/10.1007/978-94-010-9423-8_44
Publisher Name: Springer, Dordrecht
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