Abstract
In a previous study1 we noticed that long-term ovariectomy (50–70 days) resulted in (a) a significant increase of the weight of the thymus, both absolute and relative, and (b) in a decrease of the relative adrenal weight when compared to intact rats of similar age. On the other hand, the administration of oestradiol benzoate (300 Mg/kg) for three consecutive days and a three day interval was followed by a significant decrease of the thymus weight, both absolute and relative and an increase of the relative adrenal weight reaching the level of thymus and adrenals found in intact rats.
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References
Sfikakis, A., Sfikakis, P. and Varonos, D. (1980). Oestradiol induced interaction between adrenals and thymus in the female rat. Acta Endocrinol. Copenhagen), Suppl. (In press)
Hayness, R. C. Jr. and Larner, J. (1975) Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs. In Goodman, L.S. and Gilman, A. (eds.) The Pharmacological Basis of Therapeutics. 5th Edn, pp. 1472–1506. (New York: Macmillan)
Currey, H. L. F. and Ziff, M. (1968). Suppression of adjuvant disease in the rat by heterologous anti-lymphocyte globulin. 7. Exp. Med., 127, 185
Sfikakis, A., Kyriakos, G., Messari, J. and Varonos, D. (1979). Effets de l’oestradiol sur les glandes préputiales, les surrenales et les androgènes sériques chez la rate castrée. Ann. Endocrinol. Comptes rendus de la 15e réunion des Endocrinologues de langue Française, 40, 11
Coyne, M. D. and Kitay, J. (1963). Effects of ovariectomy on pituitary secretion of ACTH. Endocrinology, 85, 1097
Blake, C. A., Norman, R. L. and Sawyer, C. H. (1972). Effects of oestrogen and/or progesterone on serum and pituitary gonadotropin levels in ovariectomized rats. Proc. Soc. Exp. Biol. Med., 141, 1100
Colby, H. D. (1979). Mechanism of action of prolactin on adrenocortical steroid secretion in hypophysectomized female rats. Endocrinology, 104, 1299
Ogle, Th. F. and Kitay, J. I. (1979). Interaction of prolactin and adrenocorticotropin in the regulation of adrenocortical secretion in female rats. Endocrinology, 104, 40
Cohen, H., Freedman, H. H., Kleinberg, W., Schechter, N. R. and Martin, G.J. (1954). Enhancement of corticotrophic activity: Effect on adrenal and thymus weights. Endocrinology, 54, 81
Mueller, M.N. and Kappas, A. (1964) Estrogen Pharmacology II. Suppression of experimental immune polyarthritis (29715). Proc. Soc. Exp. Biol. Med., 117, 845
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Sfikakis, A., Karamanis, K., Laiou, C., Sfikakis, P., Varonos, D. (1980). Possible synergism between ovariectomy and oestradiol in preventing Freund’s adjuvant arthritis in the rat. In: Willoughby, D.A., Giroud, J.P. (eds) Inflammation: Mechanisms and Treatment. Inflammation: Mechanisms and Treatment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9423-8_19
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DOI: https://doi.org/10.1007/978-94-010-9423-8_19
Publisher Name: Springer, Dordrecht
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