Abstract
Many actions on gastrointestinal functions(1–6) have been demonstrated for TRH since it has been located in the gastrointestinal tract(7). Excitatory effects of TRH on duodenal and colonic motilities in anaesthetized rabbits(8,9) and rats(10) have been related to central administration of the peptide. Preliminary results have shown that small doses of TRH inactive under anaesthesia when given by intracerebroventricular (ICV) and intravenous (IV) routes, have induced an hyperactivity of the gastroduodenal junction at a dosage of 1 (ICV) to 5 (IV) in the conscious animal. We have examined, therefore, the effects on the patterns of small intestine electrical activity of an ICV vs. IV administration of TRH in conscious rats, either fasted or fed, under anaesthesia and after different pretreatments.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Morley, J.E., Steinbach, J.H., Feldman, E.J. and Solomon, T.E. (1979). The effects of thyrotropin-releasing hormone ( TRH) on the gastrointestinal tract. Life Sci., 24, 1059–66.
Morley, J.E., Levine, A.S. and Silvis, S.E. (1981). Endogenous opiates inhibit gastric acid secretion induced by central administration of thyrotropin-releasing hormone (TRH). Life Sci., 29, 293–7.
Bruce, L.A., Behsudi, F.M. and Fawcett, C.P. (1979). Histaminergic involvement in thyrotropin-releasing hormone stimulation of antral tissue in the rat. Gastroenterology, 76, 908–12.
Dolva, L.D. and Hanssen, K.F. (1982). Thyrotropin-releasing hormone: Distribution and actions in the gastrointestinal tract. Scand. J. Gastroenterol., 17, 705–7.
Soldani, G., Del Tacca, M., Martino, E., Bartelloni, A. and Impicciatore, M. (1983). The involvement of the vagal pathway in the antisecretory effect of thyrotropin-releasing hormone on gastric secretion in the dog. J. Pharm. Pharmacol., 35, 119–21.
Maeda-Hagiwara, M. and Watanabe, K. (1983). Influence of dopamine receptor agonists on gastric acid secretion induced by intraventricular administration of thyrotropin-releasing hormone in the perfused stomach of anaesthetized rats. Br. J. Pharmacol., 79, 297–303.
Martino, E., Lenmark, A., Seo, H., Steiner, D.F. and Refetoff, S. (1978). High concentration of thyrotropin-releasing hormone in pancreatic islets. Proc. Natl Acad. Sci USA, 75, 4265–8.
Smith, J.R., La Hann, T.R., Chesnut, R.M., Carino, M.A. and Horita, A. (1977). Thyrotropin-releasing hormone: Stimulation of colonic activity following intracerebroventricular administration. Science, 196, 660–2.
La Hann, T.R. and Horita, A. (1982). Thyrotropin-releasing hormone: Centrally mediated effects on gastrointestinal motor activity. J. Pharmacol. Exp. Ther., 222, 66–70.
Tonoue, T. and Nomoto, T. (1979). Effect of intracerebroventricular administration of thyrotropin-releasing hormone upon the electroenteromyogram of rat duodenum. Eur. J. Pharmacol., 58, 365–77.
Ferré, J.P. (1981). Motricité gastro-intestinale chez le rat. Nature et variations physio-pathologiques. Thèse Doct. 3e cycle, Toulouse.
Kalivas, P.W. and Horita, A. (1979). Thyrotropin-releasing hormone: Central site of action in antagonism of pentobarbital narcosis. Nature, 178, 461–2.
Mitsuma, T. and Nogimori, K. (1983). Influence of the route of administration on TRH concentration in the mouse brain. Experientia, 39, 620–2.
Rostad, H. (1973). Colonic motility in the cat. III. Influence of hypothalamic and mesencephalic stimulation. Acta Physiol. Scand., 89, 104–15.
Yarbrough, G.G. (1983). Thyrotropin-releasing hormone and CNS cholinergic neurons. Life Sci., 33, 111–8.
Drust, E. and Connor, J.D. (1983). Pharmacological analysis of shaking behavior induced by enkephalins, thyrotropin-releasing hormone or serotonin in rats: Evidence for different mechanisms. J. Pharmacol. Exp. Ther., 224, 148–54.
Rojdmark, S., Andersson, D.E.H., Edstrom, E. and Lamminpaa, K. (1983). Serum calcium decline after intravenous administration of TRH in man. Horm. Metab. Res., 15, 290–3.
Knudtzon, J. and Hanssen, L.E. (1983). TRH increases plasma somatostatin-like immunoreactivity in rabbits. Horm. Metab. Res., 15, 309–10.
Buéno, L. and Ferré, J.P. (1982). Central regulation of intestinal motility by somatostatin and cholecystokinin octapeptide. Science, 216, 1427–9.
Sharif, N.A. and Burt, D.R. (1983). Receptors for thyrotropin releasing hormone ( TRH) in rabbit spinal cord. Brain Res., 270, 259–64.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 MTP Press Limited
About this chapter
Cite this chapter
Ruckebusch, Y., Soldani, G., Ferré, J.R. (1984). Central Effects of Thyrotropin-Releasing Hormone on Gastrointestinal Motility in Fasted and Fed Rats. In: Roman, C. (eds) Gastrointestinal Motility. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9352-1_92
Download citation
DOI: https://doi.org/10.1007/978-94-010-9352-1_92
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-9354-5
Online ISBN: 978-94-010-9352-1
eBook Packages: Springer Book Archive