Abstract
As is evident from the variety of topics covered in this book, skin, as an organ, performs a number of diverse functions. One is to control the transport of physiologically important material to and from the body, and to prevent so far as possible the ingress of foreign substances. It is this role of skin as a barrier which is of prime interest here. Studies in this area contribute to the further understanding of the structure and function of skin, and have the additional practical importance that transdermal drug delivery has in some circumstances attractive advantages over other methods of drug administration1.
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References
Barry, B.W. (1983). Dermatological Formulations, Percutaneous Absorption. (New York, Basel: Dekker)
McKenzie, A.W. and Stoughton, R.B. (1962). Method for comparing percutaneous absorption of steroids. Arch. Dermatol., 86, 608–610
Clanachan, I., Devitt, H.G., Foreman, M.I. and Kelly, I.P. (1980). The human vasoconstrictor assay for topical steroids. J. Pharmacal. Methods, 4, 209–220
Barry, B.W. and Woodford, R. (1986). The vasoconstrictor test as a model for developing topical formulations. In (eds.) Marks, R. and Plewig, G. Skin Models. pp 103–112. (Berlin: Springer Verlag)
Stoughton, R.B., Clendenning, W.E. and Kruse, D. (1960). Percutaneous absorption of nicotinic acid and derivatives. J. Invest. Dermatol., 35, 337–341
Guy, R.H., Hadgraft, J. and Malbach, H.I. (1982). A pharmacokinetic model for percutaneous absorption. Int. J. Pharm., 11, 119–124
Scheuplein, R.J. and Blank, I.H. (1973). Mechanisms of percutaneous absorption. IV. Penetration of non-electrolytes (alcohols) from aqueous solutions and from pure liquids. J. Invest. Dermatol., 66, 286–296
Washitake, M., Yajima, T., Anmo, T., Arita, T. and Hori, R. (1973). Studies on percutaneous absorption of drugs. III. Percutaneous absorption of drugs through damaged skin. Chem. Pharm. Bull., 21, 2444–24451
Takeda, Y. (1975). An autoradiographic study on the percutaneous absorption of a topical corticosteroid with reference to the effects of occlusion and stripping. J. Dermatol., 2, 131–6
Tregear, R.T. (1961). Relative penetrability of hair follicles and epidermis. J. Physiol., 156, 307–13
Scheuplein, R.J. (1967). Mechanism of percutaneous absorption. II. Transient diffusion and the relative importance of various routes of skin penetration. J. Invest. Dermatol., 48, 79–88
Scheuplein, R.J. (1972). Properties of the skin as a membrane. In (eds.) Stoughton, R.B. and Van Scott, E.J. Pharmacology and the Skin. Chap. X, pp 125–152. (New York: Appleton-Century-Crofts)
Scheuplein, R.J. and Blank, I.H. (1971). Permeability of the skin. Physiol. Rev., 51, 702–747
Foreman, M.I., Picton, W., Lukowiecki, G.A. and Clark, C. (1979). The effect of topical crude coal tar on unstimulated hairless hamster skin. Br. J. Dermatol., 100, 707–715
Foreman, M.I., Clanachan, I. and Kelly, I.P. (1983). Diffusion barriers in skin, a new method of comparison. Br. J. Dermatol., 108, 549–53
Hsia, S.L. and Lee, H.Y. (1966). Metabolic transformations of cortisol-414C in human skin. Biochemistry, 5, 1469–74
Hershey, F.B., Lewis Jr., C., Murphy, J. and Schiff, T. (1960). Quantitative histochemistry of human skin. J. Histochem. Cytochem., 8, 41–9
Crank, J. (1970). The Mathematics of Diffusion. (Oxford: Oxford University Press)
Daynes, H. (1920). The process of diffusion through a rubber membrane. Proc. R. Soc., A97, 286–307
Berger, J.E. and Helm, F. (1970). Flurandrenolone tape. New means of achieving occlusive therapy. N. Y. State J. Med., 70, 406–408
Vickers, C.F.H. (1963). Existence of a reservoir in the stratum corneum — experimental proof. Arch. Dermatol., 88, 20–25
Scheuplein, R.J. and Ross, L.W. (1974). Mechanism of percutaneous absorption. V. Percutaneous absorption of solvent deposited solids. J. Invest. Dermatol., 62, 353–360
Foreman, M.I. (1986). Stratum corneum hydration; consequences for skin permeation experiments. Drug. Dev. Ind. Pharm., 12, 461–463
Foreman, M.I., Kelly, I. and Lukowiecki, G.A. (1977). A method for the measurement of diffusion constants suitable for studies of non-occluded skin. J. Pharm. Pharmacol., 29, 108–109
Van Duzee, B.F. (1975). Thermal analysis of human stratum corneum. J. Invest. Dermatol., 65, 404–408
Foreman, M.I. and Clanachan, I. (1984). Steroid diffusion and binding in human stratum corneum. J. Chem. Soc. Faraday Trans., 1, 80, 3439–3444
Feldman, R.J. and Maibach, H.I. (1965). Penetration of 14C-hydrocortisone through normal skin. Arch. Dermatol., 91, 661–666
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Foreman, M.I. (1988). A critical review of percutaneous penetration studies. In: Marks, R.M., Barton, S.P., Edwards, C. (eds) The Physical Nature of the Skin. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1291-5_10
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DOI: https://doi.org/10.1007/978-94-009-1291-5_10
Publisher Name: Springer, Dordrecht
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