Abstract
Macrocyclic and macrobicyclic ligands may enhance the stability of their metal complexes due to the inherent entropic and kinetic properties of a ligand ring or cage-type structure. In general, as the binding site becomes more encapsulated or preformed the reorganization entropy decreases, leading to a relatively higher formation constant for metal binding. Thus it would be expected that the formation constants be greatest for the series macrobicyclic > macrocyclic > exocyclic (Figure 1).
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© 1989 Kluwer Academic Publishers
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Raymond, K.N. (1989). Template Synthesis of Ligands for Highly Charged Metal Cations. In: Gokel, G.W., Koga, K. (eds) United States-Japan Seminar on Host-Guest Chemistry. Advances in Inclusion Science, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0969-4_19
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DOI: https://doi.org/10.1007/978-94-009-0969-4_19
Publisher Name: Springer, Dordrecht
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