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Atherosclerosis-related effects of verapamil, anipamil and other calcium antagonists studied on cell culture

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Abstract

It has been shown that calcium antagonists suppress experimental atherosclerosis in animals (1). Recently it was demonstrated that nifedipine and verapamil suppress the development of human coronary atherosclerosis and induce regression of atherosclerosis in patients (2.3). The mechanisms of antiatherogenic (preventive) and antiatherosclerotic (leading to regression) actions of calcium antagonists remain obscure.

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References

  1. Blumlein S.L., Sievers R., Kidd P., Parmley W.W. (1985). Modification of experimental atherosclerosis by calcium-channel blockers. Am J Cardiol, 55, 165B–171B.

    Article  PubMed  Google Scholar 

  2. Kober G., Schneider W., Kaltenbach M. (1989). Can the progression of coronary sclerosis be influenced by calcium antagonists? J Cardiovasc Pharmacol, 13, S2–S6.

    Article  PubMed  Google Scholar 

  3. Lichtlen P.R., Hugenhoitz P.G., Rafflenbeul W., INTACT-group (1989). Possible protective effect of nifedipine against progression of atherosclerosis in man (INTACT-study). In: “4th International Symposium on Calcium Antagonists: Pharmacology and CLinical Research. Abstract Book”, Florence (Italy), pp. 127–130.

    Google Scholar 

  4. Orekhov A.N., Tertov V.V., Kudryashov S.A. et al. (1986). Primary culture of human aortic intima cells as a model for testing antiatherosclerotic drugs. Effects of cyclic AMP, prostaglandins, calcium antagonists, antioxidants, and lipid-lowering agents. Atherosclerosis, 60, 101–110.

    Article  CAS  PubMed  Google Scholar 

  5. Orekhov A.N., Tertov V.V., Khashimov Kh.A. et al. (1986). Antiatherosclerotic effects of verapamil in primary culture of human aortic intimal cells. J Hypertension, 4, S153–S155.

    CAS  Google Scholar 

  6. Orekhov A.N., Tertov V.V., Khashimov Kh.A. et al. (1987). Evidence of antiatherosclerotic action of verapamil from direct effects on arterial cells. Am J Cardiol, 59, 495–496.

    Article  CAS  PubMed  Google Scholar 

  7. Orekhov A.N., Baldenkov G.N., Tertov V.V, et al. (1988). Cardiovascular drugs and atherosclerosis: effects of calcium antagonists, beta-blockers, and nitrates on atherosclerotic characteristics of human aortic cells. J Cardiovasc Pharmacol, 12, S66–S68.

    Article  CAS  PubMed  Google Scholar 

  8. Baldenkov G.N., Akopov S.E., Li H.R.. Orekhov A.N. (1988). Prostacyclin, thromboxane A and calcium antagonists: effects on atherosclerotic characteristics of vascular cells. Biomed Biochini Acta, 47, S324–S327.

    CAS  Google Scholar 

  9. Orekhov A.N., Tertov V.V., Novlkov I.D. et al. (1985). Lipids in cells of atherosclerotic and uninvolved human aorta. I. Lipid composition of aortic tissue and enzyme isolated and cultured cells. Exp Mol Pathol, 42, 117–137.

    Article  CAS  PubMed  Google Scholar 

  10. Bligh E.G., Dyer W.J. (1959). A rapid method of total lipid extraction and purification. Can J Biochem Physiol, 37, 911–917.

    Article  CAS  PubMed  Google Scholar 

  11. Dixon W.J., Brown M.B. (1977). Biomedical Computer Programs. P-Series. University of California Press, Berkeley, pp. 185–198.

    Google Scholar 

  12. Chazov E.I., Tertov V.V., Orekhov A.N. et al. (1986). Atherogenicity of blood serum from patients with coronary heart disease. Lancet, 2, 595–598.

    Article  CAS  PubMed  Google Scholar 

  13. Orekhov A.N., Tertov V.V., Pokrovsky S.N. et al. (1988). Blood serum atherogenicity associated with coronary atherosclerosis. Evidence for nonlipid factor providing atherogenicity of low-density lipoproteins and an approach to its elimination. Circ Res, 62, 421–429.

    CAS  PubMed  Google Scholar 

  14. Chazov E.I., Orekhov A.N., Tertov V.V. et al. (1988). Atherogenicity of blood plasma from patients with coronary atherosclerosis and its correction. Atherosclerosis Rev, 17, 9–20.

    Google Scholar 

  15. Tertov V.V., Orekhov A.N., Martsenyuk O.N. et al. (1989). Low density lipoproteins isolated from the blood of patients with coronary heart disease induce the accumulation of lipids in human aortic cells. Exp Mol Pathol, 50, 337–347.

    Article  CAS  PubMed  Google Scholar 

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© 1990 Kluwer Academic Publishers

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Orekhov, A.N., Tertov, V.V., Pivovarova, E.M., Kozlov, S.G., Lyakishev, A.A., Ruda, M.Y. (1990). Atherosclerosis-related effects of verapamil, anipamil and other calcium antagonists studied on cell culture. In: Descovich, G., Gaddi, A., Magri, G., Lenzi, S. (eds) Atherosclerosis and Cardiovascular Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0731-7_46

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  • DOI: https://doi.org/10.1007/978-94-009-0731-7_46

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6814-7

  • Online ISBN: 978-94-009-0731-7

  • eBook Packages: Springer Book Archive

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