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Infectious Complications

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The Transplantation and Replacement of Thoracic Organs

Abstract

In 1981 Reitz and his co-workers at Stanford University successfully introduced heart—lung transplantation into clinical practice1, 2. Although the new form of transplantation was rapidly taken up by other centers, the pace of further development has been significantly slowed by the scarcity of suitable heart—lung donors. It was also soon appreciated that heart—lung recipients are at risk for a number of serious complications in the postoperative period, the most important of which are intrathoracic infections, particularly pneumonias3. These complications account for the fact that the healthy survival of heart—lung recipients is worse than other major organ transplant recipients3–5.

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References

  1. Reitz, B.A., Wallwork, J.L., Hunt, S.A., Pennock, J.L., Billingham, M.E., Oyer, P.E., Stinson, E.B. and Shumway, N.E. (1982). Heart—lung transplantation. Successful therapy for patients with pulmonary vascular disease. N. Engl. J. Med., 306, 557

    Article  PubMed  CAS  Google Scholar 

  2. Jamieson, S.W, Reitz, B.A., Oyer, P.E. et al. (1983). Combined heart and lung transplantation. Lancet, 1, 1130

    Article  PubMed  CAS  Google Scholar 

  3. Griffith, B.P. (1987). Cardiopulmonary transplantation — growing pains. Int. J. Cardiol., 17, 119

    Article  PubMed  CAS  Google Scholar 

  4. Morris, A.J.R. and Jamieson, S.W. (1987). Combined heart—lung transplantation for end-stage right ventricular failure. Cardiol. Clin., 17, 251

    CAS  Google Scholar 

  5. Thompson, M.E., Dummer, J.S., Paradis, I., Zeevi, A., Griffith, B.P. and Hardesty, R.L. (1987). Heart—lung transplantation — the courage to succeed. In Yu, P. (ed.) Progress in Cardiology. Vol. 16 (3). (Philadelphia: Lea and Febiger)

    Google Scholar 

  6. Pollard, R.B., Rand, K.H., Gamberg, P., Gallagher, J.G. and Merigan, T.C. (1982). Specific cell mediated immunity and infections with herpesvirus in cardiac transplant recipients. Am. J. Med., 73, 679

    Article  PubMed  CAS  Google Scholar 

  7. Luft, B.J., Naot, Y., Araujo, F.G., Stinson, E.B. and Remington, J.S. (1983). Primary and reactivated toxoplasma infection in patients with cardiac transplants. Ann. Intern. Med., 99, 27

    PubMed  CAS  Google Scholar 

  8. Wreghitt, T.G., Hakim, M., Cory-Pearce, R., English, T.A.H. and Wallwork, J. (1986). The impact of donor-transmitted CMV and Toxomplasma gondii disease in cardiac transplantation. Transplant. Proc., 18, 1375

    Google Scholar 

  9. Siegelman, S.S., Sinha, S.B.P. and Veith, F.J. (1973). Pulmonary reimplantation response. Ann. Surg., 177, 30

    Article  Google Scholar 

  10. Jamieson, S.W., Stinson, E.B., Oyer, P.E., Reitz, B.A., Baldwin, J., Modry, D., Dawkins, K., Theodore, J., Hunt, S. and Shumway, N.E (1984). Heart—lung transplantation for irreversible pulmonary hypertension. Ann. Thorac. Surg., 38, 554

    Article  PubMed  CAS  Google Scholar 

  11. Mancini, M.C., Borovetz, H.S., Griffith, B.P. and Hardesty, R.L. (1985). Changes in lung vascular permeability after heart—lung transplantation. J. Surg. Res., 39, 305

    Article  PubMed  CAS  Google Scholar 

  12. Dauber, J.H. and Zeevi, A. (1988). Lung transplantation: lessons learned about local immune function and pulmonary defense mechanisms. In Daniele, R.P. (ed.) Pulmonary Immunology, p. 625. (New York: McGraw Hill)

    Google Scholar 

  13. Mancini, M.C. and Tauxe, W.N. (1986). Assessment of pulmonary clearance in heart—lung transplant recipients using technetium99 minimicronized albumin colloid (MMAC). Am. Rev. Respir. Dis., 133, All

    Google Scholar 

  14. Paradis, I.L., Marrari, M., Zeevi, A., Duquesnoy, R.J., Griffith, B.P., Hardesty, R.L. and Dauber, J.H. (1985). HLA phenotype of lung lavage cells following heart—lung transplantation. J. Heart Transplant., 4, 422

    PubMed  CAS  Google Scholar 

  15. Fung, J.J., Zeevi, A., Kaufman, C., Paradis, I.L., Dauber, J.H., Hardesty, R.L., Griffith, B. and Duquesnoy, R.J. (1985). Interactions between lymphocytes and macrophages in heart—lung transplant recipients. Human Immunol., 14, 287

    Article  CAS  Google Scholar 

  16. Zeevi, A., Fung, J.J., Paradis, I.L., Dauber, J.H., Griffith, B.P, Hardesty, R.L. and Duquesnoy, R.J. (1985). Lymphocytes of bronchoalveolar lavage from heart—lung transplant recipients. J. Heart Transplant., 4, 417

    PubMed  CAS  Google Scholar 

  17. Zeevi, A, Fung, J.J, Paradis, I.L, Gryzan, S, Dauber, J.H, Hardesty, R.L, Griffith, B, Trento, A, Saidman, S. and Duquesnoy, R.J. (1987). Bronchoalveolar macrophage—lymphocyte reactivity in heart—lung transplant recipients. Transplant. Proc., 19, 2537

    PubMed  CAS  Google Scholar 

  18. Muggenburg, B.A, Bice, D.E, Haley, P.J, Mauderly, J.L, Dauber, J.J, Heron, K. and Griffith, B.P. (1987). Immune response in the transplanted canine lung. Am. Rev. Respir. Dis., 135, A103

    Google Scholar 

  19. Brooks, R.G, Hofflin, J.M, Jamieson, S.W, Stinson, E.B. and Remington, J.S. (1985). Infectious complications in heart—lung transplant recipients. Am. J. Med., 79, 412

    Article  PubMed  CAS  Google Scholar 

  20. Dummer, J.S, Montero, C.G, Griffith, B.P, Hardesty, R.L, Paradis, I.L. and Ho, M. (1986). Infections in heart—lung transplant recipients. Transplantation, 41, 725

    Article  PubMed  CAS  Google Scholar 

  21. Griffith, B.P, Kormos, R.L, Hardesty, R.L, Armitage, J.M. and Dummer, J.S. (1988). The artificial heart: infection-related morbidity and its effect on transplantation. Ann. Thorac. Surg., 45, 409

    Article  PubMed  CAS  Google Scholar 

  22. Ho, M. (1982). Cytomegalovirus: Biology and Infection. (New York: Plenum Press)

    Google Scholar 

  23. Dummer, J.S, White, L.T, Ho, M, Griffith, B.P, Hardesty, R.L. and Bahnson, H.T. (1985). Morbidity of cytomegalovirus infection in recipients of heart or heart—lung transplants who received cyclosporine. J. Infect. Dis., 152, 1182

    Article  PubMed  CAS  Google Scholar 

  24. Meyers, J.D, Flournoy, N. and Thomas, E.D. (1982). Nonbacterial pneumonia after allogeneic marrow transplantation: a review of ten years’ experience. Rev. Infect. Dis., 4, 1119

    Article  PubMed  CAS  Google Scholar 

  25. Shepp, D.H, Danliker, P.S, Miranda, P, Burnette, T.C, Cederberg, D.M, Kirk, L.E. and Meyers, J.D. (1985). Activity of 9-[2-hydroxyl-l-(hydroxymethyl) ethoxymethyl] guanine in the treatment of cytomegalovirus pneumonia. Ann. Intern. Med., 103, 368

    PubMed  CAS  Google Scholar 

  26. Erice, A, Jordon, M.C, Chace, B.A, Fletcher, C, Chinnock, B.J. and Balfour, H.H. Jr. (1987). Ganciclovir treatment of cytomegalovirus disease in transplant recipients and other immunocompromised hosts. J. Am. Med. Assoc., 257, 3082

    Article  CAS  Google Scholar 

  27. Syndman, D.R, Werner, B.G, Heinze-Lacey, B, Berardi, V.P, Tilney, N.L, Kirkman, R.L, Milford, E.L, Cho, S.I, Bush H.L. Jr., Levey, A.S, Strom, T.B, Carpenter, C.B, Levey, R.H, Harmon, W.E, Zimmerman, C.E, Shapiro, M.E, Steinman, T, Logerfo, F, Idelson, B., Schroter, G.P.J, Levin, M.J, McIves, J, Leszczyrski, J. and Grady, G.F. (1987). Use of cytomegalovirus immune globulin to prevent cytomegalovirus disease in renal transplant recipients. N. Engl. J. Med., 317, 1049

    Article  Google Scholar 

  28. Ho, M, Miller, G, Atchison, R.W, Breinig, M.K, Dummer, J.S, Andeman, W, Starzl, T.E, Eastman, R, Griffith, B.P, Hardesty, R.L, Bahnson, H.T, Hakala, T.R. and Rosenthal, J.T. (1985). Epstein-Barr virus infections and DNA hybridization studies in posttransplantation lymphoma and lymphoproliferative lesions: The role of primary infection. J. Infect. Dis., 152, 876

    Article  PubMed  CAS  Google Scholar 

  29. Beveridge, T, Krupp, P. and McKibbin, C. (1984). Lymphomas and lymphoproliferative lesions developing under cyclosporine therapy (Letter). Lancet, 1, 788

    Article  PubMed  CAS  Google Scholar 

  30. Hanto, D, Frizzera, G, Gajl-Peczalska, K. and Simmons, R. (1985). Epstein—Barr virus, immunodeficiency and B-cell lymphoproliferation. Transplantation, 39, 461

    Article  PubMed  CAS  Google Scholar 

  31. Starzl, T.E, Nalesnik, M.A., Porter, K.A, Ho, M, Iwatsuki, S, Griffith, B.P, Rosenthal, J.T, Hakala, T.R, Shaw, B.W. Jr., Hardesty, R.L. et al. (1984). Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporine-steroid therapy. Lancet, 1, 583

    Article  PubMed  CAS  Google Scholar 

  32. Allen, M.D, Burke, C.M, McGregor, C.G.A, Baldwin, J.C, Jamieson, S.W. and Theodore, J. (1986). Steroid-responsive bronchiolitis after human heart—lung transplantation. J. Thorac. Cardiovasc. Surg., 92, 449

    PubMed  CAS  Google Scholar 

  33. Dummer, J.S, Bahnson, H.T, Griffith, B.P, Hardesty, R.L, Thompson, M.E. and Ho, M. (1983). Infections in patients on cyclosporine and prednisone following cardiac transplantation. Transplant. Proc., 15, 2779

    Google Scholar 

  34. Dummer, J.S, Ho, M, McMahon, D.K, Griffith, B.P, Hardesty, R.L, Trento, A. and Bahnson, H.T. (1987). Infectious complications in heart and heart—lung transplant recipients. Proceedings of the 1st European Conference on Transplantation, Venice, Italy, March 1987

    Google Scholar 

  35. Steffenson, D.O., Dummer, J.S, Granick, M.S., Pasculle, A.W, Griffith, B.P. and Cassell, G.H. (1987). Sternotomy infections with Mycoplasma hominis. Ann. Intern. Med., 106, 204

    PubMed  CAS  Google Scholar 

  36. Bygdeman, S.M. and Mardh, P.A. (1984). Antimicrobial susceptibility and susceptibility testing of Mycoplasma hominis. Sex. Trans. Dis., 11, 366

    Article  CAS  Google Scholar 

  37. Kenny, T, Hooten, M. and Roberts, M.C. (1987). Sensitivities of Mycoplasma hominis and Ureaplasma urealyticum to quinolones. Abstracts of the International Conference on Antimicrobial Agents and Chemotherapy, New York

    Google Scholar 

  38. Griffith, B.P, Hardesty, R.L, Trento, A. and Bahnson, H.T. (1985). Asynchronous rejection of heart and lungs following cardiopulmonary transplantation. Ann. Thorac. Surg., 40, 488

    Article  PubMed  CAS  Google Scholar 

  39. Griffith, B.P, Durham, S.J, Hardesty, R.L, Trento, A. and Paradis, I.L. (1987). Acute rejection of the heart—lung allograft and methods of its detection. Transplant. Proc., 19, 2527

    PubMed  CAS  Google Scholar 

  40. Novitzky, D, Cooper, D.K.C, Wicomb, W.N, Rose, A.G. and Reichart, R. (1985). Transplantation of the heart and both lungs. S. Afr. Med. J., 67, 575

    PubMed  CAS  Google Scholar 

  41. Yousem, S.A., Burke, C.M. and Billingham, M.E. (1985). Pathologic pulmonary alterations in long-term human heart—lung transplantation. Hum. Pathol, 16, 911

    Article  PubMed  CAS  Google Scholar 

  42. Theodore, J, Jamieson, S.W, Burke, C.M, Reitz, B.A, Stinson, E.B, Van Kessel, A, Dawkins, K.D, Herran, J.J, Oyer, P.E, Hunt, S.A., Shumway, N.E. and Robin, E.D. (1984). Physiologic aspects of human heart—lung transplantation. Chest, 86, 349

    Article  PubMed  CAS  Google Scholar 

  43. Burke, C.M, Theodore, J, Dawkins, K.D, Yousem, S.A., Blank, N, Billingham, M.E, Van Kessel, A, Jamieson, S.W, Oyer, P.E, Baldwin, J.C, Stinson, E.B, Shumway, N.E. and Robin, E.D. (1984). Post-transplant obliterative bronchiolitis and other late lung sequelae in human heart—lung transplantation. Chest, 86, 824

    Article  PubMed  CAS  Google Scholar 

  44. Gryzan, S, Paradis, I.L, Zeevi, A. et al. (1988). Unexpectedly high incidence of Pneumocystis carinii infection after lung—heart transplantation: implications for lung defense and allograft survival. Am. Rev. Respir. Dis., 137, 1268

    PubMed  CAS  Google Scholar 

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Authors
  1. J. S. Dummer
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Editor information

Editors and Affiliations

  1. Baptist Medical Center, Oklahoma Transplantation Institute, Oklahoma City, Oklahoma, USA

    David K. C. Cooper MA, MD, PhD, FRCS (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) & Dimitri Novitzky MD, FCS (SA) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery) (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) &  (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery)

  2. University of Cape Town Medical School and Groote Schuur Hospital, Cape Town, South Africa

    David K. C. Cooper MA, MD, PhD, FRCS (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery)

  3. Groote Schuur Hospital, Cape Town, South Africa

    Dimitri Novitzky MD, FCS (SA) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery)

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© 1990 Kluwer Academic Publishers

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Dummer, J.S. (1990). Infectious Complications. In: Cooper, D.K.C., Novitzky, D. (eds) The Transplantation and Replacement of Thoracic Organs. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0711-9_41

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  • DOI: https://doi.org/10.1007/978-94-009-0711-9_41

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6805-5

  • Online ISBN: 978-94-009-0711-9

  • eBook Packages: Springer Book Archive

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