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Genetic factors in animal models of intestinal inflammation

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Inflammatory Bowel Disease

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Abstract

Clinical investigators have compellingly documented a genetic component in ulcerative colitis and Crohn’s disease1. There is an increased incidence of inflammatory bowel disease (IBD) in family members, a predilection for these disorders in certain genetically defined ethnic groups, higher concordance of disease in monozygotic versus dizygotic twins, and familial patterns of clinical phenotypes. However, human genetic research has not yet provided clinically useful disease susceptibility markers, or an understanding of the immunopathogenesis of IBD.

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Authors
  1. R. B. Sartor
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Editor information

Editors and Affiliations

  1. Division of Gastroenterology, The University of Calgary, Alberta, Canada

    L. R. Sutherland (Professor of Medicine, Head) (Professor of Medicine, Head)

  2. Division of Gastroenterology, McMaster University, Faculty of Health Sciences, Hamilton, Ontario, Canada

    S. M. Collins (Chief) (Chief)

  3. Division of Gastroenterology, St Luc Hospital, Montreal, Quebec, Canada

    F. Martin (Professor of Medicine, Chief) (Professor of Medicine, Chief)

  4. Department of Surgery, University of Toronto, Mount Sinai Hospital, Toronto, Ontario, Canada

    R. S. McLeod (Head of the Clinical Epidemiology Program, Associate Professor) (Head of the Clinical Epidemiology Program, Associate Professor)

  5. Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California, USA

    S. R. Targan (Director) (Director)

  6. Health Sciences Center, University of Calgary, Calgary, Alberta, Canada

    J. L. Wallace (Professor of Medical Physiology and Medicine) (Professor of Medical Physiology and Medicine)

  7. Division of Gastroenterology, Dalhousie University, Halifax, Nova Scotia, Canada

    C. N. Williams (Professor and Head) (Professor and Head)

  8. Faculty of Medicine, Clinical Research Center, Halifax, Nova Scotia, Canada

    C. N. Williams (Professor and Head) (Professor and Head)

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© 1994 Kluwer Academic Publishers and Axcan Pharma, Inc.

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Sartor, R.B. (1994). Genetic factors in animal models of intestinal inflammation. In: Sutherland, L.R., et al. Inflammatory Bowel Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0371-5_2

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  • DOI: https://doi.org/10.1007/978-94-009-0371-5_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6653-2

  • Online ISBN: 978-94-009-0371-5

  • eBook Packages: Springer Book Archive

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