Skip to main content

Risk of cancer in transplant patients treated with recombinant growth hormone

  • Chapter
Cancer in Transplantation: Prevention and Treatment

Part of the book series: Transplantation and Clinical Immunology ((TRAC,volume 27))

Abstract

Growth hormone (GH) is a potent stimulator of insulin-like growth factor- 1 (IGF-1), which in its turn has been proven to stimulate both cell proliferation and protein synthesis in various systems. Thus, the question may be raised whether the therapeutic use of GH, particularly in transplant patients, may increase the risk of developing malignant tumors or causing recurrence of a previous tumor that is thought to be under control [1].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Ritzén EM. Does growth hormone increase the risk of malignancies? Horm Res 1993; 39: 99–101.

    Article  PubMed  Google Scholar 

  2. Zadik Z, Estrov Z, Karov Y, Hahn T, Barak Y. The effect of growth hormone and IGF-1 on clonogenic growth of hematopoietic cells in leukemic patients during active disease and durning remission — A preliminary report. J Pediatr Endocrinol 1993; 6: 79–83.

    Article  PubMed  CAS  Google Scholar 

  3. Ogilvy-Stuart AL, Shalet SM. Tumour occurrence and recurrence. Horm Res 1992; 38 (suppl 1): 50–55.

    Article  PubMed  Google Scholar 

  4. Wilton R Adverse effect during growth hormone treatment: 5 years’ experience in the Kabi International Growth Study. In: Ranke MB, Gunnarsson R, editors. Progress in Growth Hormone Therapy — 5 years of the KIGS. Mannheim, Germany: J & J Verlag, 1994: 291–307.

    Google Scholar 

  5. Stahnke N. Leukemia in growth-hormone-treated patients: an update, 1992. Horm Res 1992; 38 (suppl 1): 56–62.

    Article  PubMed  Google Scholar 

  6. Butturini A, Bernasconi S, Izzi G, Gertner JM, Gale RP. Short stature, Fanconi’s anemia, and risk of leukaemia after growth hormone therapy. Lancet 1994; 343: 1576.

    Article  PubMed  CAS  Google Scholar 

  7. Watanabe S, Mizuno S, Oshima LH, Tsunematsu Y, Fujimoto J, Komiyama A. Leukemia and other malignancies among GH users. J Pediatr Endocrinol 1993; 6: 99–108.

    Article  PubMed  CAS  Google Scholar 

  8. Momoi T, Yamanaka C, Yorifuji T et al. Wilms tumour in a patient with growth hormone replacement therapy. Eur J Pediatr 1989; 149: 159–161.

    Article  PubMed  CAS  Google Scholar 

  9. Bourguignon JP, Pierard E, Ernould C et al. Effects of human growth hormone therapy on melanocytic naevi. Lancet 1993; 341: 1505–1506.

    Article  PubMed  CAS  Google Scholar 

  10. Petersen BH, Rapaport R, Henry DP, Huseman C, Moore WV. Effect of treatment with biosynthetic human growth hormone on peripheral blood lymphocyte populations and function in growth hormone-deficient children. J Clin Endocrinol Metab 1990; 70: 1756–1760.

    Article  PubMed  CAS  Google Scholar 

  11. Tönshoff B, Haffner D, Mehls O et al. Efficacy and safety of growth hormone treatment in short children with renal allografts: three year experience. Kidney Int 1993; 44:199–207.

    Article  PubMed  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Kluwer Academic Publishers

About this chapter

Cite this chapter

Cochat, P., Saïd, MH., Lesage, C., Gouffrant, C., Berlier, P. (1996). Risk of cancer in transplant patients treated with recombinant growth hormone. In: Touraine, J.L., Traeger, J., Bétuel, H., Dubernard, J.M., Revillard, J.P., Dupuy, C. (eds) Cancer in Transplantation: Prevention and Treatment. Transplantation and Clinical Immunology, vol 27. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0175-9_15

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-0175-9_15

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6563-4

  • Online ISBN: 978-94-009-0175-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics