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The St Thomas’ Atherosclerosis Regression Study and an appraisal of its potential limitations

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Book cover Lipid-Lowering Therapy and Progression of Coronary Atherosclerosis

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 180))

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Summary

The principal findings and potential limitations of the St Thomas’ Atherosclerosis Regression Study (STARS) are presented. STARS was a randomized endpoint blinded study of the effects of lipid-lowering therapy on angiographic coronary artery disease (CAD) in male patients with hypercholesterolemia. Both a fat-modified diet and diet-plus cholestyramine favourably influenced the course of CAD over 3 years. As discussed in this paper, the study did, however, have some limitations in respect of its sample size, use of angiography and generalizability of the findings.

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Authors
  1. G. F. Watts
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Editor information

Editors and Affiliations

  1. Department of Cardiology, University Hospital Leiden, P.O. Box 9600, 2300 RC, Leiden, The Netherlands

    Albert V. G. Bruschke

  2. Department of Diagnostic Radiology and Nuclear Medicine, University Hospital Leiden, P.O. Box 9600, 2300 RC, Leiden, The Netherlands

    Johan H. C. Reiber

  3. University of Amsterdam, The Netherlands

    K. I. Lie

  4. Interuniversity Cardiology Institute of The Netherlands, P.O. Box 19258, 3501 DG, Utrecht, The Netherlands

    Hein J. J. Wellens

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© 1996 Kluwer Academic Publishers

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Watts, G.F. (1996). The St Thomas’ Atherosclerosis Regression Study and an appraisal of its potential limitations. In: Bruschke, A.V.G., Reiber, J.H.C., Lie, K.I., Wellens, H.J.J. (eds) Lipid-Lowering Therapy and Progression of Coronary Atherosclerosis. Developments in Cardiovascular Medicine, vol 180. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0143-8_13

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  • DOI: https://doi.org/10.1007/978-94-009-0143-8_13

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6551-1

  • Online ISBN: 978-94-009-0143-8

  • eBook Packages: Springer Book Archive

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