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Adherens Junction Turnover: Regulating Adhesion Through Cadherin Endocytosis, Degradation, and Recycling

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Book cover Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease

Part of the book series: Subcellular Biochemistry ((SCBI,volume 60))

Abstract

Adherens junctions are important mediators of intercellular adhesion, but they are not static structures. They are regularly formed, broken, and rearranged in a variety of situations, requiring changes in the amount of cadherins, the main adhesion molecule in adherens junctions, present at the cell surface. Thus, endocytosis, degradation, and recycling of cadherins are crucial for dynamic regulation of adherens junctions and control of intercellular adhesion. In this chapter, we review the involvement of cadherin endocytosis in development and disease. We discuss the various endocytic pathways available to cadherins, the adaptors involved, and the sorting of internalized cadherin for recycling or lysosomal degradation. In addition, we review the regulatory pathways controlling cadherin endocytosis and degradation, including regulation of cadherin endocytosis by catenins, cadherin ubiquitination, and growth factor receptor signaling pathways. Lastly, we discuss the proteolytic cleavage of cadherins at the plasma membrane.

An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-94-007-4186-7_18

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Acknowledgements

We would like to thank Victor Faundez as well as members of the Kowalczyk lab for insightful and engaging conversations during the preparation of this manuscript. We would also like to acknowledge funding from the National Institutes of Health (R01AR050501 and R01AR048266 to APK). BAN was supported by a fellowship from the American Heart Association (11PRE7590097).

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Authors and Affiliations

  1. Department of Cell Biology, Emory University School of Medicine, 30332, Atlanta, GA, USA

    Andrew P. Kowalczyk & Benjamin A. Nanes

  2. Department of Dermatology, Emory University School of Medicine, 30332, Atlanta, GA, USA

    Benjamin A. Nanes

  3. Graduate Program in Biochemistry, Cell and Developmental Biology, Emory University School of Medicine, 30332, Atlanta, GA, USA

    Andrew P. Kowalczyk

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  1. Andrew P. Kowalczyk
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  2. Benjamin A. Nanes
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Correspondence to Andrew P. Kowalczyk .

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  1. , Cell and Systems Biology, University of Toronto, Harbord Street 25, Toronto, M5S 3G5, Ontario, Canada

    Tony Harris

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Kowalczyk, A.P., Nanes, B.A. (2012). Adherens Junction Turnover: Regulating Adhesion Through Cadherin Endocytosis, Degradation, and Recycling. In: Harris, T. (eds) Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease. Subcellular Biochemistry, vol 60. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4186-7_9

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