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Aging Research in Yeast pp 207–232Cite as

Yeast Aging and Apoptosis

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Part of the book series: Subcellular Biochemistry ((SCBI,volume 57))

Abstract

A concerted balance between proliferation and apoptosis is essential to the survival of multicellular organisms. Thus, apoptosis per se, although it is a destructive process leading to the death of single cells, also serves as a pro-survival mechanism that ensures healthy organismal development and acts as a life-prolonging or anti-aging program. The discovery that yeast also possess a functional and, in many cases, highly conserved apoptotic machinery has made it possible to study the relationships between aging and apoptosis in depth using a well-established genetic system and the powerful tools available to yeast researchers for investigating complex physiological and cytological interactions. The aging process of yeast, be it replicative or chronological aging, is closely related to apoptosis, although it remains unclear whether apoptosis is a causal feature of the aging process or vice versa. Nevertheless, experimental results obtained during the past several years clearly demonstrate that yeast serve as a powerful and versatile experimental system for understanding the interconnections between these two fundamentally important cellular and physiological pathways.

Equally contributed by Peter Laun, Sabrina Büttner, Mark Rinnerthaler

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Acknowledgements

We are grateful to the Austrian Science Fund FWF (Vienna, Austria) for grants S9302-B05 (to M.B.) and T414-B09 (to S.B.) and to the EC (Brussels, Europe) for project MIMAGE (contract no. 512020; to M.B.).

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Authors and Affiliations

  1. Division of Genetics, Department of Cell Biology, University of Salzburg, Salzburg, Austria

    Peter Laun, Mark Rinnerthaler & Michael Breitenbach

  2. Institute of Molecular Biosciences, University of Graz, Graz, Austria

    Sabrina Büttner

  3. Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY, 14222, USA

    William C. Burhans

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  1. Peter Laun
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  2. Sabrina Büttner
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  3. Mark Rinnerthaler
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  4. William C. Burhans
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  5. Michael Breitenbach
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Correspondence to Peter Laun .

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Editors and Affiliations

  1. , Department of Cell Biology, University of Salzburg, Hellbrunnerstrasse 34, Salzburg, 5020, Austria

    Michael Breitenbach

  2. , Tulane Center for Aging and Department o, Tulane University Health Sciences Center, Tulane Avenue SL-12 1430, New Orleans, 70112, Louisiana, USA

    S. Michal Jazwinski

  3. , Department of Cell Biology, University of Salzburg, Hellbrunnerstrasse 34, Salzburg, 5020, Austria

    Peter Laun

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Laun, P., Büttner, S., Rinnerthaler, M., Burhans, W.C., Breitenbach, M. (2011). Yeast Aging and Apoptosis . In: Breitenbach, M., Jazwinski, S., Laun, P. (eds) Aging Research in Yeast. Subcellular Biochemistry, vol 57. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2561-4_10

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