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Mechanostransduction in Cardiac and Stem-Cell Derived Cardiac Cells

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Mechanosensitivity of the Heart

Part of the book series: Mechanosensitivity in Cells and Tissues ((MECT,volume 3))

Abstract

This review focuses on mechanoelectric feedback and mechanotransduction in cardiac cells and stem-cell derived cardiomyocyte progenitor cells. Topics include: methods to apply mechanical stimuli to isolated cells and tissues; methods for patterned growth of cells; effects of stretch and shear stress on cellular function and tissue electrophysiology; regulation of structural and junctional proteins by stretch; the role of the cytoskeleton in mechanotransduction and heart failure; signaling pathways involved in mechanotransduction and load-induced hypertrophic responses; and the role of substrate stiffness in stem cell differentiation and maturation of excitation-contraction coupling.

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Authors and Affiliations

  1. Department of Bioengineering, Rice University, Congenital Heart Surgery, Texas Children’s Hospital, Houston, TX, USA

    Jeffrey G. Jacot

  2. Saint Jude Medical, Los Angeles, CA, USA

    Anna J. Raskin

  3. Department of Bioengineering, University of California, San Diego, CA, USA

    Jeffrey H. Omens & Andrew D. McCulloch

  4. Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, USA

    Leslie Tung

Authors
  1. Jeffrey G. Jacot
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  2. Anna J. Raskin
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  3. Jeffrey H. Omens
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  4. Andrew D. McCulloch
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  5. Leslie Tung
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Corresponding author

Correspondence to Leslie Tung .

Editor information

Editors and Affiliations

  1. Dept. Fundamental &, Russian State Medical University, Ostrovitjanova Str. 1, Moskva, 117997, Russian Federation

    Andre Kamkin

  2. Dept. Fundamental &, Russian State Medical University, Ostrovitjanova Str. 1, Moskva, 117997, Russian Federation

    Irina Kiseleva

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Jacot, J.G., Raskin, A.J., Omens, J.H., McCulloch, A.D., Tung, L. (2010). Mechanostransduction in Cardiac and Stem-Cell Derived Cardiac Cells. In: Kamkin, A., Kiseleva, I. (eds) Mechanosensitivity of the Heart. Mechanosensitivity in Cells and Tissues, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2850-1_5

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