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Regulation of pRB and p53 Pathways by the Long Noncoding RNAs ANRIL, lincRNA-p21, lincRNA-RoR, and PANDA

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Long Noncoding RNAs

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Abstract

Retinoblastoma protein (pRB) and p53 pathways play a key role in controlling the cell cycle and apoptosis in response to oncogenic insults and DNA damage. Disruption of these pathways deregulates the control of cell proliferation and represents a common event in the development of most types of human cancer. Recent studies have revealed that several long noncoding RNAs (lncRNAs) are involved in the regulation of pRB and p53 pathways, through transcriptional and translational control of target genes. In this chapter, we focus on four lncRNAs: ANRIL, lincRNA-p21, lincRNA-RoR, and PANDA. These lncRNAs are involved in the pRB and p53 pathways. ANRIL associates with and recruits polycomb proteins to repress the transcription of cyclin-dependent kinase (CDK) inhibitor p15 and p16 genes, resulting in the repression of pRB function. lincRNA-p21, lincRNA-RoR, and PANDA are induced by p53 in response to DNA damage and regulate apoptosis. We discuss the involvement of ANRIL, lincRNA-p21, lincRNA-RoR, and PANDA in cellular functions through the pRB and p53 pathways, and the molecular mechanisms by which these lncRNAs regulate the expression of target genes.

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Authors and Affiliations

  1. Department of Biological and Environmental Chemistry, Faculty of Humanity-Oriented Science and Engineering, Kinki University, 11-6 Kayanomori, Iizuka, Fukuoka, 820-8555, Japan

    Yojiro Kotake

  2. Department of Molecular Biology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, 431-3192, Japan

    Masatoshi Kitagawa

Authors
  1. Yojiro Kotake
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  2. Masatoshi Kitagawa
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Correspondence to Yojiro Kotake .

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Editors and Affiliations

  1. Division of Gene Structure and Function, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan

    Riki Kurokawa

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Kotake, Y., Kitagawa, M. (2015). Regulation of pRB and p53 Pathways by the Long Noncoding RNAs ANRIL, lincRNA-p21, lincRNA-RoR, and PANDA . In: Kurokawa, R. (eds) Long Noncoding RNAs. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55576-6_10

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