Abstract
Multicenter trials in orthopedic surgery can have substantial advantages over single-center trials, including increasing enrollment resulting in enhanced statistical power and increased diversity of providers and patient populations resulting in improved generalizability of results (Chung et al., Plast Reconstr Surg. 126(2):515–23, 2010). However, they have a unique set of challenges related to the need for coordination and cooperation across multiple sites. In this chapter we use the JUPITER (Justifying Patellar Instability Treatment by Early Results) study as an example and discuss how a multicenter trial can be divided into several stages: discussion, planning, execution, and presentation/publication. At each stage, it is critically important that the investigators work closely together in a collaborative and supportive fashion and are willing to compromise work toward consensus. Specific recommendations regarding the conduct of orthopedic multicenter trials are provided.
JUPITER Group—Elizabeth A. Arendt, MD; Jackie Brady, MD; Dennis Crawford, MD; Diane L. Dahm, MD; Henry Ellis, MD; Matthew Halsey, MD; Peter Fabricant, MD; Jack Farr, MD; Dan Green, MD; Benton Heyworth, MD; Kosmas Kayes, MD; Dennis Kramer, MD; Aaron Krych, MD; Robert Magnussen, MD; Todd Milbrandt, MD; Matthew Milewski, MD; Charlie Popkin, MD; Lauren Redler, MD; David Roberts, MD; Verena Schreiber, MD; Seth Sherman, MD; Sabrina Strickland, MD; Marc Tompkins, MD; Eric Wall, MD; Philip Wilson, MD; Yi-Meng Yen, MD
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References
Askenberger M, Janarv PM, Finnbogason T, Arendt EA. Morphology and anatomic patellar instability risk factors in first-time traumatic lateral patellar dislocations: a prospective magnetic resonance imaging study in skeletally immature children. Am J Sports Med. 2017;45(1):50–8.
Christensen TC, Sanders TL, Pareek A, Mohan R, Dahm DL, Krych AJ. Risk factors and time to recurrent ipsilateral and contralateral patellar dislocations. Am J Sports Med. 2017;45(9):2105–10.
Chung KC, Song JW, Group WS. A guide to organizing a multicenter clinical trial. Plast Reconstr Surg. 2010;126(2):515–23.
Hulley SB, Cummings SR, Browner WS, Grady DG, Newman TB. Designing clinical research: an epidemiologic approach. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2006.
Jaquith BP, Parikh SN. Predictors of recurrent patellar instability in children and adolescents after first-time dislocation. J Pediatr Orthop. 2017;37(7):484–90.
Koh JL, Stewart C. Patellar instability. Orthop Clin North Am. 2015;46(1):147–57.
Krych AJ, O’Malley MP, Johnson NR, Mohan R, Hewett TE, Stuart MJ, et al. Functional testing and return to sport following stabilization surgery for recurrent lateral patellar instability in competitive athletes. Knee Surg Sports Traumatol Arthrosc. 2018;26(3):711–8.
Sanders TL, Pareek A, Hewett TE, Stuart MJ, Dahm DL, Krych AJ. High rate of recurrent patellar dislocation in skeletally immature patients: a long-term population-based study. Knee Surg Sports Traumatol Arthrosc. 2018;26(4):1037–43.
Tompkins MA, Arendt EA. Patellar instability factors in isolated medial patellofemoral ligament reconstructions—what does the literature tell us? A systematic review. Am J Sports Med. 2015;43(9):2318–27.
Vavken P, Wimmer MD, Camathias C, Quidde J, Valderrabano V, Pagenstert G. Treating patella instability in skeletally immature patients. Arthroscopy. 2013;29(8):1410–22.
Weber AE, Nathani A, Dines JS, Allen AA, Shubin-Stein BE, Arendt EA, et al. An algorithmic approach to the management of recurrent lateral patellar dislocation. J Bone Joint Surg Am. 2016;98(5):417–27.
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Koh, J.L., Parikh, S., Stein, B.S., The JUPITER Group. (2019). Conducting a Multicenter Trial: Learning from the JUPITER (Justifying Patellar Instability Treatment by Early Results) Experience. In: Musahl, V., et al. Basic Methods Handbook for Clinical Orthopaedic Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-58254-1_44
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DOI: https://doi.org/10.1007/978-3-662-58254-1_44
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