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Cytomegaloviruses pp 189–220Cite as

Cellular and Molecular Basis of the Protective Immune Response to Cytomegalovirus Infection

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 154))

Abstract

Cytomegalovirus (CMV) infection can occur throughout life. Similar to other herpesviruses, after primary infection CMV remains in the host in a latent state. Infection of the immunocompetent host does not cause clinical symptoms, whereas infection of the immunocompromised host can cause severe and even fatal disease. Morbidity and mortality associated with primary CMV infection or with reactivation from latency is common in immunosuppressed transplant recipients and in patients with immunodeficiency caused by HIV infection. CMV pneumonia is considered the immediate cause of death in these patients.

This work was supported by The Deutsche Forschungsgemeinschaft grant Ko 571/578 and SFB 322. M. Del Val received a fellowship by the Alexander-von-Humboldt Foundation

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Authors and Affiliations

  1. Department of Virology, Institute for Microbiology, University of Ulm, D-7900, Ulm, Germany

    U. H. Koszinowski, M. Del Val & M. J. Reddehase

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  1. U. H. Koszinowski
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  2. M. Del Val
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  3. M. J. Reddehase
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Editors and Affiliations

  1. Fred Hutchinson Cancer Research Center, University of Washington, 1124, Columbia Street, Seattle, WA, 98104, USA

    James K. McDougall PhD. (Research Professor of Pathology, Member) (Research Professor of Pathology, Member)

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© 1990 Springer-Verlag Berlin Heidelberg

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Koszinowski, U.H., Del Val, M., Reddehase, M.J. (1990). Cellular and Molecular Basis of the Protective Immune Response to Cytomegalovirus Infection. In: McDougall, J.K. (eds) Cytomegaloviruses. Current Topics in Microbiology and Immunology, vol 154. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74980-3_8

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  • DOI: https://doi.org/10.1007/978-3-642-74980-3_8

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