Abstract
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system of unknown etiology, but a disease in which immunopathologic events are likely important [1]. It is a chronic disease, frequently with an clinically relapsing course [2], but the pathologic processes may actually be continuous, although accentuated at times [3]. It also has a restricted age distribution, with the peak onset between 20 and 40 years of age. In addition to the inflammation, which is predominantly made up of monocyte-macrophage-microglia and lymphocytes and/ or their progeny, and demyelination, the other characteristic pathologic feature is gliosis [4]. This gliosis relates to the astrocytes, although there is some controversy as to whether these cells become more prominent, increase in number, or both.
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Keywords
- Multiple Sclerosis
- Major Histocompatibility Complex
- Glial Cell
- Multiple Sclerosis Patient
- Experimental Allergic Encephalomyelitis
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Lisak, R.P. (1988). Glial Cells and Products of Activated Inflammatory Cells: Implications for Pathogenesis and Treatment of Multiple Sclerosis. In: Cazzullo, C.L., Caputo, D., Ghezzi, A., Zaffaroni, M. (eds) Virology and Immunology in Multiple Sclerosis: Rationale for Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73032-0_3
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