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Biomembranes pp 160–176Cite as

The Role of the Na+/K+ Pump in Normal and Cancer Cell Proliferation

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Abstract

The well-characterized basic functions of the Na+/K+ pump include: (1) maintenance of the transmembrane Na+ and K+ gradients over the plasma membrane, which is a prerequisite for the generation of the resting membrane potential and the action potential; (2) generation of the transmembrane electrochemical potential gradient for Na+ ions which provides the energy for the uphill movements of H+ and Ca2+ ions as well as sugars and amino acids through the appropriately coupled transfer devices; (3) maintenance of the high [K+] environment which is required for the optimum activity of many intracellular enzymes involved in energy generation and macromolecule synthesis. In the outcome, the Na+/K+ pump plays a key role in the regulation of normal cellular homeostasis, cell differentiation and cell proliferation.

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  1. Energy Conversion Unit, Central Institute of Molecular Biology, Academy of Sciences of GDR, 1115, Berlin, Germany

    Kurt R. H. Repke

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  1. Department of Cellular Biology Faculty of Medicine, Medical and Pharmaceutical Institute, 3400, Cluj-Napoca, Roumania

    Gheorghe Benga

  2. Laboratory of Biochemistry, University of Amsterdam, 1000 HD, Amsterdam, The Netherlands

    Joseph M. Tager

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Repke, K.R.H. (1988). The Role of the Na+/K+ Pump in Normal and Cancer Cell Proliferation. In: Benga, G., Tager, J.M. (eds) Biomembranes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61374-6_10

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