Abstract
The development of less calcemic vitamin D analogs creates possible therapeutic applications for immune modulation (e.g., autoimmune diseases and graft rejection), inhibition of cell proliferation and induction of cell differentiation (e.g., cancer). Recently more insight was obtained in the mechanism of action of the analogs at the biological and molecular level. Critical remarks are summarized on why the step towards the clinic has not yet been taken and how better selective vitamin D receptor modulators could be designed.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Beer TM, Hough KM, Garzotto M, Lowe BA, Henner WD (2001) Weekly high-dose calcitriol and docetaxel in advanced prostate cancer. Semin Oncol 28:49–55
Bouillon R, Okamura WH, Norman AW (1995) Structure-function relationships in the vitamin D endocrine system. Endocr Rev 16:200–257
Bower M, Colston KW, Stein RC, Hedley A, Gazet JC, Ford HT, Combes RC (1991) Topical calcipotriol treatment in advanced breast cancer. Lancet 337 (8743):701–702
Brzozowski AM, Pike ACW, Dauter Z, Hubbard RE, Bonn T, Engstr_m O, Ohman L, Greene GL, Gustafsson JA, Carlquist M (1997) Molecular basis of agonism and antagonism in the oestrogen receptor. Nature 389:753–758
Evans TR, Colston KW, Lofts FJ, Cunningham D, Anthoney DA, Gogas H, de Bono JS, Hamberg KJ, Skov T, Mansi JL (2002) A phase II trial of the vitamin D analogue Seocalcitol (EB 1089) in patients with inoperable pacreatic cancer. Br J Cancer 86:680–685
Gulliford T, English J, Colston KW, Menday P, Moller S, Coombes RC (1998) A phase I study of EB 1089, a vitamin D analogue. Br J Cancer 78:6–13
Hansen CM, Hamberg KJ, Binderup E, Binderup L (2000) Seocalcitol (EB 1089): a vitamin D analogue of anti-cancer potential. Background, design, synthesis, pre-clinical and clinical evaluation. Curr Pharm Des 6:803–828
Howard MR, Bond LR (1999) Calcitriol in myelodysplastic syndrome. Br J Haematol 106:572–573
Mellibovsky L, Diez A, Perez-Vila E, Serrano S, Nacher M, Aubia J, Supervia A, Recker RR (1998) Vitamin D treatment in myelodysplastic syndromes. Br J Haematol 100:516–520
Osborn JL, Schwartz GG, Smith DC, Bahnson R, Day R, Trump DL (1995) Phase II trial of oral 1,25-dihydroxyvitamin D (calcitriol) in hormone refractory prostate cancer. Urol Oncol 1:195–198
Rochel N, Wurtz JM, Mitschler A, Klaholz B, Moras D (2000) Crystal structure of the nuclear receptor for vitamin D bound to its natural agonist 1α,25(OH)2 vitamin D3. Mol Cell 5:173–179
Scott LJ, Dunn CJ, Goa KL, (2001) Calcipotriol ointment. A review of its use in the management of psoriasis. Am J Clin Dermatol 2:95–120
Segaert S, Bouillon R (1998) Vitamin D and regulation of gene expression. Curr Opin Clin Nutr Metab Care 1:347–354
Trouillas P, Honnorat J, Bret P, Jouvet A, Gerard JP (2001) Redifferentiation therapy in brain tumors: long-lasting complete regression of glioblastomas and an anaplastic astrocytoma under long-term 1-alpha-hydroxycholecalciferol. J Neurooncol 51:57–66
Verboven C, Rabijns A, De Maeyer M, Van Baelen H, Bouillon R, De Ranter C (2002) A structural basis for the unique binding features of the human vitamin D-binding protein. Nature Struct Biol 9:131–136
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Bouillon, R., Verstuyf, A., Verlinden, L., Eelen, G., Mathieu, C. (2003). Prospects for Vitamin D receptor Modulators as Candidate Drugs for Cancer and (Auto)immune Diseases. In: Reichrath, J., Tilgen, W., Friedrich, M. (eds) Vitamin D Analogs in Cancer Prevention and Therapy. Recent Results in Cancer Research, vol 164. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55580-0_25
Download citation
DOI: https://doi.org/10.1007/978-3-642-55580-0_25
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-62435-3
Online ISBN: 978-3-642-55580-0
eBook Packages: Springer Book Archive