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Metabolism of N and S Methyl Groups

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Radioactive Isotopes in Physiology Diagnostics and Therapy / Künstliche Radioaktive Isotope in Physiologie Diagnostik und Therapie

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Abstract

The use of isotopically labelled compounds has revolutionized our understanding of the chemistry of living systems. Nowhere is the power of this technique more apparent than in the area of methyl metabolism for here we are dealing with the fate of but a single carbon atom. Furthermore, because only one carbon is involved it has been possible to determine if and when the methyl group moves in biochemical systems as an intact CH3 radical, and alternatively if, and when, transfer of the methyl carbon involves an oxidation-reduction reaction.

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Authors
  1. Wilhelm R. Frisell
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  2. Cosmo G. Mackenzie
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  1. Massachusetts General Hospital, Boston 14, Mass., USA

    Alan C. Aisenberg M. D., Ph. D.

  2. I. Inneren Abteilung, Allgemeinen Krankenhauses St. Georg, Hamburg 1, Lohmühlenstraße 5, Deutschland

    Hans Wilhelm Bansi Professor Dr. (Chefarzt) (Chefarzt)

  3. Radiation Laboratory, University of California, Berkeley 4, Calif., USA

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  4. Czerny-Krankenhaus, Heidelberg, Voßstraße 3, Deutschland

    J. Becker Professor Dr.  & Kurt Ernst Scheer Privatdozent  & 

  5. Herford/Westf., Bahnhofsvorplatz 2, Deutschland

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  6. College of Medicine, University of Illinois, 1853 West Polk Street, Chicago 12, Ill., USA

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  7. Donner Laboratory, University of California, Berkeley 4, Calif., USA

    James L. Born , Richard Carlson Dr. , Donald C. Van Dyke Dr. , John H. Lawrence M. D. , Franco Sangalli Dr.  & C. A. Tobias Dr. , , , ,  & 

  8. Department of Physics, Howard University, Washington 1, D.C., USA

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  9. School of Medicine, Department of Pharmacology, Yale University, 333 Cedar Street, New Haven, Conn., USA

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  10. Kernreaktor Bau- und Betriebsgesellschaft m. b. H., Karlsruhe, Weberstraße 5, Deutschland

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  13. The Worcester Foundation for Experimental Biology, Shrewsbury, Mass., USA

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  14. Laboratory of Chemical Pharmacology, Heart Institute, National Institutes of Health, Bethesda 14, Md., USA

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  15. Pathologisches Institut der Universität, Bonn-Venusberg, Deutschland

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  16. Physiologisches Institut der Universität, Freiburg i. Br., Hermann-Herder-Straße 7, Deutschland

    Albrecht Fleckenstein Professor Dr.

  17. Department of Biochemistry, School of Medicine, University of Colorado, 4200 East Ninth Avenue, Denver 20, Colo., USA

    Wilhelm R. Frisell Dr.  & Cosmo G. Mackenzie Professor Dr.  & 

  18. Kelkheim/Taunus, Mozartstraße 1, Deutschland

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  19. Chemisches Laboratorium der Universität, Freiburg i. Br., Albertstraße 21, Deutschland

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  40. The Royal Cancer Hospital, Fulham Road, London S. W. 3, UK

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  42. Medizinische Universitäts-Poliklinik, Marburg/Lahn, Robert Koch-Str. 7a, Deutschland

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  50. Columbia University, 630 West 168th Street, New York 32, N.Y., USA

    David Nachmansohn Professor Ph. D.

  51. Institut für physiologische Chemie und Physikochemie, Neue Universität, Kiel, Rudolf-Höber-Haus, Deutschland

    Hans Netter Professor Dr.

  52. New York University School of Medicine, 550 First Avenue, New York 16, N.Y., USA

    Severo Ochoa Professor Dr.

  53. Biology Division, Oak Ridge National Laboratory, Post Office Box Y, Oak Ridge, Tenn., USA

    T. T. Odell Jr. Dr.  & A. C. Upton Dr.  & 

  54. 1346 Grizzly Peak, Berkeley, Calif., USA

    M. Rothstein Dr.

  55. Merck Institute for Therapeutic Research, Rahway, N.J., USA

    Richard W. Schayer Ph. D.

  56. Meßtechn. Abteilung, Fa. Knapsack-Griesheim AG, Knapsack bei Köln, Deutschland

    Kurt Schmeiser Dr. (Leiter) (Leiter)

  57. Radiochemisches Labor, Farbwerke Hoechst AG, Deutschland

    Heinz A. E. Schmidt Dr.

  58. Max Planck-Institut für Virusforschung, Tübingen, Melanchthonstraße 36, Deutschland

    Christoph Scholtissek Dr.

  59. College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York 32, N.Y., USA

    David Shemin Professor Dr.

  60. The Rockefeller Institute for Medical Research, 66th Street and York Avenue, New York 21, N.Y., USA

    Philip Siekevitz Dr.

  61. Chemisches Laboratorium der Universität, Freiburg i. Br., Albertstr. 21, Deutschland

    Horst Sund Dr.

  62. Department of Biochemistry, School of Medicine, University of California, San Francisco 22, Calif., USA

    H. Tarver Professor Dr.

  63. Chemischen Instituts, Universität Bonn, Meckenheimer Allee 168, Deutschland

    Rudolf Tschesche Professor Dr. (Direktor) (Direktor)

  64. Pharmakologisches Institut, Zürich, Schweiz, Gloriastraße 32

    Peter Waser Professor Dr.

  65. Gif-sur Yvette (S. et O.), Frankreich, Boîte Postale 2

    Graeme Welch Dr.

  66. Physics Department, The Middlesex Hospital, Museum 833 Ext., 200 London W. 1, UK

    J. K. Whitehead M. Sc., Ph. D.

  67. I. Medizinische Universitätsklinik, München 15, Ziemssenstraße 1, Deutschland

    Hanns P. Wolff Professor Dr.

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Frisell, W.R., Mackenzie, C.G. (1961). Metabolism of N and S Methyl Groups. In: Aisenberg, A.C., et al. Radioactive Isotopes in Physiology Diagnostics and Therapy / Künstliche Radioaktive Isotope in Physiologie Diagnostik und Therapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49761-2_29

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  • DOI: https://doi.org/10.1007/978-3-642-49761-2_29

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