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Overview on Injectable Fillers: Efficacy and Safety

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Injectable Fillers in Aesthetic Medicine
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Abstract

In contrast to the USA, in most countries in Europe and South America, a great variety of injectable fillers are available. Therefore, not only for novices but also for experienced users it can sometimes be quite difficult to decide which filler to use. This chapter will give a brief overview on some of the most commonly used present and past injectable fillers. The selection of products reflects the interest of the authors and might appear arbitrary to someone familiar with other fillers.

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References

  • Alcalay J et al (2003) Late-onset granulomatous reaction to Artecoll. Dermatol Surg 29(8):859–862

    Article  PubMed  Google Scholar 

  • Andre P (2004) Evaluation of the safety of a non-animal stabilized hyaluronic acid (NASHA – Q-Medical, Sweden) in European countries: a retrospective study from 1997 to 2001. J Eur Acad Dermatol Venereol 18(4):422–425

    Article  CAS  PubMed  Google Scholar 

  • Apte RS et al (2003) Acute choroidal infarction following subcutaneous injection of micronized dermal matrix in the forehead region. Retina 23(4):552–554

    Article  PubMed  Google Scholar 

  • Ascher B, Bayerl C, Brun P, Kestemont P, Rzany B, Poncet M, Guennoun M, Podda M (2011) Efficacy and safety of a new hyaluronic acid dermal filler in the treatment of severe nasolabial lines – 6-month interim results of a randomized, evaluator-blinded, intra-individual comparison study. J Cosmet Dermatol 10:94–98

    Article  PubMed  Google Scholar 

  • Avery C, Clifford N (2010) Foreign body granulomatous reaction of the temporal region following dermal filler administration. Br J Oral Maxillofac Surg 48(6):488, Epub 2010 Jul 7

    Article  PubMed  Google Scholar 

  • Baumann L (2004) CosmoDerm/CosmoPlast (human bioengineered collagen) for the aging face. Facial Plast Surg 20(2):125–128

    Article  Google Scholar 

  • Baumann LS, Shamban AT, Lupo MP, Monheit GD, Thomas JA, Murphy DK, Walker PS, Juvéderm vs. Zyplast Nasolabial Fold Study Group (2007) Comparison of smooth-gel hyaluronic acid dermal fillers with cross-linked bovine collagen: a multicenter, double-masked, randomized, within-subject study. Dermatol Surg 33(Suppl 2):S128–S135

    Google Scholar 

  • Bergeret-Galley C et al (2001) The value of a new filler material in corrective and cosmetic surgery: Dermalive and Dermadeep. Aesthetic Plast Surg 25(4):249–255

    Google Scholar 

  • Bjarnsholt T, Tolker-Nielsen T, Givskov M, Janssen M, Christensen LH (2009) Detection of bacteria by fluorescence in situ hybridization in culture-negative soft tissue filler lesions. Dermatol Surg 35(Suppl 2):1620–1624, Epub 2009 Aug 26

    Article  CAS  PubMed  Google Scholar 

  • Brandt FS, Cazzaniga A, Baumann L, Fagien S, Glazer S, Kenkel JM, Lowe NJ, Monheit GD, Narins RS, Rendon MI, Rohrich RJ, Werschler WP (2011) Investigator global evaluations of efficacy of injectable poly-L-lactic acid versus human collagen in the correction of nasolabial fold wrinkles. Aesthet Surg J 31(5):521–528

    Article  PubMed  Google Scholar 

  • Braun M, Braun S (2008) Nodule formation following lip augmentation using porcine collagen-derived filler. J Drugs Dermatol 7(6):579–581

    PubMed  Google Scholar 

  • Breiting V et al (2004) A study on patients treated with polyacrylamide hydrogel injection for facial corrections. Aesthetic Plast Surg 28(1):45–53

    Article  PubMed  Google Scholar 

  • Callan P, Goodman GJ, Carlisle I, Liew S, Muzikants P, Scamp T, Halstead MB, Rogers JD (2013) Efficacy and safety of a hyaluronic acid filler in subjects treated for correction of midface volume deficiency: a 24 month study. Clin Cosmet Investig Dermatol 6:81–89

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Cassuto D (2009) The use of Dermicol-P35 dermal filler for nonsurgical rhinoplasty. Aesthet Surg J 29:S22–S24

    Article  PubMed  Google Scholar 

  • Cohen SR, Berner CF, Busso M, Gleason MC, Hamilton D, Holmes RE, Romano JJ, Rullan PP, Thaler MP, Ubogy Z, Vecchione TR (2006) ArteFill: a long-lasting injectable wrinkle filler material–summary of the U.S. Food and Drug Administration trials and a progress report on 4- to 5-year outcomes. Plast Reconstr Surg 118(Suppl 3):64S–76S

    Article  CAS  PubMed  Google Scholar 

  • Cohen SR, Holmes RE (2004) Artecoll: a long-lasting injectable wrinkle filler material: report of a controlled, randomized, multicenter clinical trial of 251 subjects. Plast Reconstr Surg 114(4):964–976; discussion 977–9

    Article  PubMed  Google Scholar 

  • Comite SL et al (2004) Treatment of HIV-associated facial lipoatrophy with Radiance FN (Radiesse). Dermatol Online J 10(2):2

    PubMed  Google Scholar 

  • Cooperman LS et al (1985) Injectable collagen: a six-year clinical investigation. Aesthetic Plast Surg 9(2):145–151

    Article  CAS  PubMed  Google Scholar 

  • De Boulle K, Swinberghe S, Engman M, Shoshani D (2009) Lip augmentation and contour correction with a ribose cross-linked collagen dermal filler. J Drugs Dermatol 8:1–8

    PubMed  Google Scholar 

  • De Cassia Novaes W, Berg A (2003) Experiences with a new nonbiodegradable hydrogel (Aquamid): a pilot study. Aesthetic Plast Surg 27(5):376–380

    Article  PubMed  Google Scholar 

  • Eccleston D, Murphy DK (2012) Juvéderm Volbella™ in the perioral area: a 12-month prospective, multicenter, open-label study. Clin Cosmet Investig Dermatol 5:167–172

    PubMed Central  PubMed  Google Scholar 

  • Ersek RA et al (1997) Bioplastique at 6 years: clinical outcome studies. Plast Reconstr Surg 100(6):1570–1574

    Article  CAS  PubMed  Google Scholar 

  • Fagien S (2000) Facial soft-tissue augmentation with injectable autologous and allogeneic human tissue collagen matrix (autologen and dermalogen). Plast Reconstr Surg 105(1):362–373; discussion 374–375

    Article  CAS  PubMed  Google Scholar 

  • Feeney JN, Fox JJ, Akhurst T (2009) Radiological impact of the use of calcium hydroxylapatite dermal fillers. Clin Radiol 64(9):897–902, Epub 2009 Jul 5

    Article  CAS  PubMed  Google Scholar 

  • Fernandez-Acenero MJ et al (2003) Granulomatous foreign body reaction against hyaluronic acid: report of a case after lip augmentation. Dermatol Surg 29(12):1225–1226

    Article  PubMed  Google Scholar 

  • Ficarra G et al (2002) Silicone granuloma of the facial tissues: a report of seven cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94(1):65–73

    Article  PubMed  Google Scholar 

  • Friedman PM et al (2002) Safety data of injectable nonanimal stabilized hyaluronic acid gel for soft tissue augmentation. Dermatol Surg 28(6):491–494

    Article  PubMed  Google Scholar 

  • Fulton J, Caperton C (2012) The optimal filler: immediate and long-term results with emulsified silicone (1,000 centistokes) with cross-linked hyaluronic acid. J Drugs Dermatol 11(11):1336–1341

    PubMed  Google Scholar 

  • George DA, Erel E, Waters R (2012) Patient satisfaction following Bio-Alcamid injection for facial contour defects. J Plast Reconstr Aesthet Surg 65:1622–1626

    Article  CAS  PubMed  Google Scholar 

  • Goldberg DJ (2009) Correction of tear trough deformity with novel porcine collagen dermal filler (Dermicol-P35). Aesthet Surg J 29:S9–S11

    Article  PubMed  Google Scholar 

  • Grunebaum LD, Elsaie ML, Kaufman J (2010) Six-month, double-blind, randomized, split-face study to compare the efficacy and safety of calcium hydroxylapatite (CaHA) mixed with lidocaine and CaHA alone for correction of nasolabial fold wrinkles. Dermatol Surg 36(S1):760–765

    Article  CAS  Google Scholar 

  • Hevia O (2009) Six-year experience using 1,000-centistoke silicone oil in 916 patients for soft-tissue augmentation in a private practice setting. Dermatol Surg 35(Suppl 2):1646–1652

    Article  CAS  PubMed  Google Scholar 

  • Homicz MR, Watson D (2004) Review of injectable materials for soft tissue augmentation. Facial Plast Surg 20(1):21–29

    Article  PubMed  Google Scholar 

  • Huh SY, Cho S, Kim KH, An JS, Won CH, Chang SE, Lee MW, Choi JH, Moon KC (2010) A case of complication after matridex(r) injection. Ann Dermatol 22(1):81–84

    Article  PubMed Central  PubMed  Google Scholar 

  • Jones D, Murphy DK (2013) Volumizing hyaluronic acid filler for midface volume deficit: 2-year results from a pivotal single-blind randomized controlled study. Dermatol Surg. 2013 Oct 4. [Epub ahead of print]

    Google Scholar 

  • Kim YJ, Choi KS (2013) Bilateral blindness after filler injection. Plast Reconstr Surg 131(2):298e–299e

    Article  CAS  PubMed  Google Scholar 

  • Landau M (2009) Lip augmentation and rejuvenation using Dermicol-P35 30G: personal experiences from my clinic. Aesthet Surg J. 29(3 Suppl):S12–15

    Google Scholar 

  • Lemperle G et al (1998) PMMA-Microspheres (Artecoll) for long-lasting correction of wrinkles: refinements and statistical results. Aesthetic Plast Surg 22(5):356–365

    Article  CAS  PubMed  Google Scholar 

  • Lemperle G et al (2003) Soft tissue augmentation with artecoll: 10-year history, indications, techniques, and complications. Dermatol Surg 29(6):573–587; discussion 587

    Article  PubMed  Google Scholar 

  • Lombardi T et al (2004) Orofacial granulomas after injection of cosmetic fillers. Histopathologic and clinical study of 11 cases. J Oral Pathol Med 33(2):115–120

    Article  CAS  PubMed  Google Scholar 

  • Lowe NJ (2003) Arterial embolization caused by injection of hyaluronic acid (Restylane). Br J Dermatol 148(2):379; author reply 379–380

    Article  CAS  PubMed  Google Scholar 

  • Lowe NJ et al (2001) Hyaluronic acid skin fillers: adverse reactions and skin testing. J Am Acad Dermatol 45(6):930–933

    Article  CAS  PubMed  Google Scholar 

  • Lupo MP, Smith SR, Thomas JA, Murphy DK, Beddingfield FC 3rd (2008) Effectiveness of Juvéderm Ultra Plus dermal filler in the treatment of severe nasolabial folds. Plast Reconstr Surg 121(1):289–297

    Article  CAS  PubMed  Google Scholar 

  • Lupton JR, Alster TS (2000) Cutaneous hypersensitivity reaction to injectable hyaluronic acid gel. Dermatol Surg 26(2):135–137

    Article  CAS  PubMed  Google Scholar 

  • Man J, Rao J, Goldman M (2008) A double-blind, comparative study of nonanimalstabilized hyaluronic acid versus human collagen for tissue augmentation of the dorsal hands. Dermatol Surg 34:1026–1031

    Google Scholar 

  • Manna F et al (1999) Comparative chemical evaluation of two commercially available derivatives of hyaluronic acid (hylaform from rooster combs and restylane from streptococcus) used for soft tissue augmentation. J Eur Acad Dermatol Venereol 13(3):183–192

    CAS  PubMed  Google Scholar 

  • Marmur E, Green L, Busso M (2010) Controlled, randomized study of pain levels in subjects treated with calcium hydroxylapatite premixed with lidocaine for correction of nasolabial folds. Dermatol Surg 36:309–315

    Article  CAS  PubMed  Google Scholar 

  • Marmur ES, Taylor SC, Grimes PE, Boyd CM, Porter JP, Yoo JY (2009) Six-month safety results of calcium hydroxylapatite for treatment of nasolabial folds in Fitzpatrick skin types IV to VI. Dermatol Surg 35(Suppl 2):1641–1645

    Article  CAS  PubMed  Google Scholar 

  • Massone C, Horn M, Kerl H, Ambros-Rudolph CM, Giovanna Brunasso AM, Cerroni L (2009) Foreign body granuloma due to Matridex injection for cosmetic purposes. Am J Dermatopathol 31(2):197–199

    Article  PubMed  Google Scholar 

  • Matti BA, Nicolle FV (1990) Clinical use of Zyplast in correction of age- and disease-related contour deficiencies of the face. Aesthetic Plast Surg 14(3):227–234

    Article  CAS  PubMed  Google Scholar 

  • Micheels P (2001) Human anti-hyaluronic acid antibodies: is it possible? Dermatol Surg 27(2):185–191

    Article  CAS  PubMed  Google Scholar 

  • Moers-Carpi M et al (2007) A multicenter, randomized trial comparing calcium hydroxylapatite to two hyaluronic acids for treatment of nasolabial folds. Dermatol Surg 33(Suppl 2):S144–S151

    Article  CAS  PubMed  Google Scholar 

  • Moers-Carpi MM, Tufet JO (2008) Calcium hydroxylapatite versus nonanimal stabilized hyaluronic acid for the correction of nasolabial folds: a 12-month, multicenter, prospective, randomized, controlled, split-face trial. Dermatol Surg 34(2):210–215

    Article  CAS  PubMed  Google Scholar 

  • Monstrey SJ, Pitaru S, Hamdi M, Van Landuyt K, Blondeel P, Shiri J, Goldlust A, Shoshani D (2007) A two-stage phase I trial of Evolence30 collagen for soft-tissue contour correction. Plast Reconstr Surg 120:303–311

    Article  CAS  PubMed  Google Scholar 

  • Moody BR, Sengelmann RD (2000) Self-limited adverse reaction to human-derived collagen injectable product. Dermatol Surg 26(10):936–938

    Article  CAS  PubMed  Google Scholar 

  • Moyle GJ et al (2004) A randomized open-label study of immediate versus delayed polylactic acid injections for the cosmetic management of facial lipoatrophy in persons with HIV infection. HIV Med 5(2):82–87

    Article  CAS  PubMed  Google Scholar 

  • Nadarajah JT, Collins M, Raboud J, Su D, Rao K, Loutfy MR, Walmsley S (2012) Infectious Complications of Bio-Alcamid Filler Used for HIV-Related Facial Lipoatrophy. Clin Infect Dis 55:1568–1574

    Article  PubMed  Google Scholar 

  • Narins RS et al (2003) A randomized, double-blind, multicenter comparison of the efficacy and tolerability of Restylane versus Zyplast for the correction of nasolabial folds. Dermatol Surg 29(6):588–595

    Article  PubMed  Google Scholar 

  • Narins RS, Baumann L, Brandt FS, Fagien S, Glazer S, Lowe NJ, Monheit GD, Rendon MI, Rohrich RJ, Werschler WP (2010a) A randomized study of the efficacy and safety of injectable poly-L-lactic acid versus human-based collagen implant in the treatment of nasolabial fold wrinkles. J Am Acad Dermatol 62(3):448–462

    Article  CAS  PubMed  Google Scholar 

  • Narins RS, Brandt FS, Lorenc ZP, Maas CS, Monheit GD, Smith SR (2008) Twelve-month persistency of a novel ribose-cross-linked collagen dermal filler. Dermatol Surg 34(Suppl 1):S31–S39

    Article  CAS  PubMed  Google Scholar 

  • Narins RS, Brandt FS, Lorenc ZP, Maas CS, Monheit GD, Smith SR, McIntyre S (2007) A randomized, multicenter study of the safety and efficacy of Dermicol-P35 and non-animal-stabilized hyaluronic acid gel for the correction of nasolabial folds. Dermatol Surg 33(Suppl 2):S213–S221; discussion S21

    Article  CAS  PubMed  Google Scholar 

  • Narins RS, Coleman WP 3rd, Rohrich R, Monheit G, Glogau R, Brandt F, Bruce S, Colen L, Dayan S, Jackson I, Maas C, Rivkin A, Sclafani A, Spivak JC (2010b) 12-Month controlled study in the United States of the safety and efficacy of a permanent 2.5 % polyacrylamide hydrogel soft-tissue filler. Dermatol Surg 36(Suppl 3):1819–1829

    Article  CAS  PubMed  Google Scholar 

  • Narins RS, Coleman W, Donofrio L, Jones DH, Maas C, Monheit G, Kaur M, Grundy SL, Pappert EJ, Hardas B (2010c) Nonanimal sourced hyaluronic acid-based dermal filler using a cohesive polydensified matrix technology is superior to bovine collagen in the correction of moderate to severe nasolabial folds: results from a 6-month, randomized, blinded, controlled, multicenter study. Dermatol Surg 36(1):730–740

    Article  CAS  Google Scholar 

  • Nast A, Reytan N, Hartmann V, Pathirana D, Bachmann F, Erdmann R, Rzany B (2011) Efficacy and durability of two hyaluronic acid-based fillers in the correction of nasolabial folds: results of a prospective, randomized, double-blind, actively controlled clinical pilot study. Dermatol Surg 37:768–775

    Article  CAS  PubMed  Google Scholar 

  • Orentreich DS (2000) Liquid injectable silicone: techniques for soft tissue augmentation. Clin Plast Surg 27(4):595–612

    CAS  PubMed  Google Scholar 

  • Palm MD, Woodhall KE, Butterwick KJ, Goldman MP (2010) Cosmetic use of poly-l-lactic acid: a retrospective study of 130 patients. Dermatol Surg 36:161–170

    Article  CAS  PubMed  Google Scholar 

  • Perry CM (2004) Poly-L-lactic acid. Am J Clin Dermatol 5(5):361–366; discussion 367–368

    Article  PubMed  Google Scholar 

  • Pinsky MA, Thomas JA, Murphy DK, Walker PS, Juvéderm vs. Zyplast Nasolabial Fold Study Group (2008) Juvéderm injectable gel: a multicenter, double-blind, randomized study of safety and effectiveness. Aesthet Surg J 28(1):17–23. doi:10.1016/j.asj.2007.09.005

    Article  CAS  PubMed  Google Scholar 

  • Protopapa C et al (2003) Bio-Alcamid in drug-induced lipodystrophy. J Cosmet Laser Ther 5(3–4):226–230

    Article  PubMed  Google Scholar 

  • Rapaport MJ et al (1996) Injectable silicone: cause of facial nodules, cellulitis, ulceration, and migration. Aesthetic Plast Surg 20(3):267–276

    Article  CAS  PubMed  Google Scholar 

  • Raulin C et al (2000) Exudative granulomatous reaction to hyaluronic acid (Hylaform). Contact Dermatitis 43(3):178–179

    CAS  PubMed  Google Scholar 

  • Requena C et al (2001) Adverse reactions to injectable aesthetic microimplants. Am J Dermatopathol 23(3):197–202

    Article  CAS  PubMed  Google Scholar 

  • Rossner F, Roßner M, Hartmann V, Erdmann R, Wiest LG, Rzany B (2009a) Decrease of reported adverse events to injectable polylactic acid after recommending an increased dilution: eight year results from the Injectable Filler Safety-Study (IFS-Study). J Cosmet Dermatol 8(1):14–18

    Google Scholar 

  • Rossner M, Roßner F, Bachmann F, Wiest L, Rzany B (2009b) Increased risk of severe adverse reactions towards an injectable filler composed of a fixed combination of methacrylate particles and hyaluronic acid (Dermalive®). Dermatol Surg 35(Suppl 1):367–374

    Google Scholar 

  • Rzany B et al (2004) Anwendung von Polymilchsäure (New-Fill) in der Ästhetischen Medizin: Ergebnisse des ersten deutschen Konsensustreffens an der Charité. Ästhetische Dermatologie 3

    Google Scholar 

  • Rzany B, Hilton S, Prager W, Hartmann V, Brandl G, Fischer TC, Gekeler O, Glöckner S, Gramlich G, Hartmann M, Lederman K, Luckner-Neugebauer J, Pavicic T, Stangl S, Walker T, Zenker S, Wolters M (2010) Expert guideline on the use of porcine collagen in aesthetic medicine. J Dtsch Dermatol Ges 8:210–217

    Article  PubMed  Google Scholar 

  • Rzany B, Bayerl C, Bodokh I, Boineau D, Dirschka T, Queille-Roussel C, Sebastian M, Sommer B, Poncet M, Guennoun M, Podda M (2011) Efficacy and safety of a new hyaluronic acid dermal filler in the treatment of moderate nasolabial folds: 6-month interim results of a randomized, evaluator-blinded, intra-individual comparison study. J Cosmet Laser Ther 13:107–112

    Article  PubMed  Google Scholar 

  • Rzany B, Cartier H, Kestemont P, Trevidic P, Sattler G, Kerrouche N, Dhuin JC, Ma YM (2012) Full-face rejuvenation using a range of hyaluronic acid fillers: efficacy, safety, and patient satisfaction over 6 months. Dermatol Surg 38(7 Pt 2):1153–1161

    Article  CAS  PubMed  Google Scholar 

  • Sadick NS, Palmisano L (2009) Cheek augmentation with Dermicol-P35 27G. Aesthet Surg J 29:S5–S8

    Article  PubMed  Google Scholar 

  • Saray A (2003) Porcine dermal collagen (Permacol) for facial contour augmentation: preliminary report. Aesthetic Plast Surg 27(5):368–375

    Article  PubMed  Google Scholar 

  • Schelke LW, van den Elzen HJ, Canninga M, Neumann MH (2009) Complications after treatment with polyalkylimide. Dermatol Surg 35(Suppl 2):1625–1628

    Article  CAS  PubMed  Google Scholar 

  • Schierle CF, Casas LA (2011) Nonsurgical rejuvenation of the aging face with injectable poly-L-lactic acid for restoration of soft tissue volume. Aesthet Surg J 31(1):95–109

    Article  PubMed  Google Scholar 

  • Schuller-Petrović S, Pavlović MD, Schuller SS, Schuller-Lukić B, Neuhold N (2013) Early granulomatous foreign body reactions to a novel alginate dermal filler: the system’s failure? J Eur Acad Dermatol Venereol 27(1):121–123

    Article  PubMed  Google Scholar 

  • Sclafani AP et al (2000) Autologous collagen dispersion (Autologen) as a dermal filler: clinical observations and histologic findings. Arch Facial Plast Surg 2(1):48–52

    Article  CAS  PubMed  Google Scholar 

  • Sclafani AP et al (2002a) Rejuvenation of the aging lip with an injectable acellular dermal graft (Cymetra). Arch Facial Plast Surg 4(4):252–257

    Article  PubMed  Google Scholar 

  • Sclafani AP et al (2002b) Homologous collagen dispersion (dermalogen) as a dermal filler: persistence and histology compared with bovine collagen. Ann Plast Surg 49(2):181–188

    Article  PubMed  Google Scholar 

  • Shafir R et al (2000) Long-term complications of facial injections with Restylane (injectable hyaluronic acid). Plast Reconstr Surg 106(5):1215–1216

    Article  CAS  PubMed  Google Scholar 

  • Shoshani D, Markovitz E, Cohen Y, Heremans A, Goldlust A (2007) Skin test hypersensitivity study of a cross-linked, porcine collagen implant for aesthetic surgery. Dermatol Surg 33(Suppl 2):S152–S158

    Article  CAS  PubMed  Google Scholar 

  • Silvers SL, Eviatar JA, Echavez MI, Pappas AL (2006) Prospective, open-label, 18-month trial of calcium hydroxylapatite (Radiesse) for facial soft-tissue augmentation in patients with human immunodeficiency virus-associated lipoatrophy: one-year durability. Plast Reconstr Surg 118(Suppl 3):34S–45S

    Article  CAS  PubMed  Google Scholar 

  • Sklar JA, White SM (2004) Radiance FN: a new soft tissue filler. Dermatol Surg 30(5):764–768; discussion 768

    Article  PubMed  Google Scholar 

  • Smith S, Busso M, McClaren M, Bass LS (2007) A randomized, bilateral, prospective comparison of calcium hydroxylapatite microspheres versus human-based collagen for the correction of nasolabial folds. Dermatol Surg 33(Suppl 2):S112–S121

    Article  CAS  PubMed  Google Scholar 

  • Sperling B, Bachmann F, Hartmann V, Erdmann R, Wiest L, Rzany B (2010) The current state of treatment of adverse reactions to injectable fillers. Dermatol Surg 36(Suppl 3):1895–1904

    Article  CAS  PubMed  Google Scholar 

  • Sung MS, Kim HG, Woo KI, Kim YD (2010) Ocular ischemia and ischemic oculomotor nerve palsy after vascular embolization of injectable calcium hydroxylapatite filler. Ophthal Plast Reconstr Surg 26(4):289–291

    Article  PubMed  Google Scholar 

  • Tzikas TL (2004) Evaluation of the Radiance FN soft tissue filler for facial soft tissue augmentation. Arch Facial Plast Surg 6(4):234–239

    Article  PubMed  Google Scholar 

  • Valantin MA et al (2003) Polylactic acid implants (New-Fill®) to correct facial lipoatrophy in HIV-infected patients: results of the open-label study VEGA. AIDS 17(17):2471–2477

    Article  CAS  PubMed  Google Scholar 

  • Wang YB et al (2003) Clinically analyzing the possible side-effects after injecting hydrophilic poly-acrylamide gel as a soft-tissue filler. Zhonghua Zheng Xing Wai Ke Za Zhi 19(5):328–330

    PubMed  Google Scholar 

  • Waris E (2003) Alloplastic injectable biomaterials for soft tissue augmentation: a report on two cases with complications associated with a new material (Dermalive) and a review of the literature. Eur J Plast Surg 26:350–355

    Google Scholar 

  • Webster RC et al (1986) Injectable silicone for facial soft-tissue augmentation. Arch Otolaryngol Head Neck Surg 112(3):290–296

    Article  CAS  PubMed  Google Scholar 

  • Woerle B et al (2004) Poly-L-lactic acid: a temporary filler for soft tissue augmentation. J Drugs Dermatol 3(4):385–389

    PubMed  Google Scholar 

  • Zielke H, Wölber L, Wiest L, Rzany B (2008) Risk profiles of different injectable fillers: results from the Injectable Filler Safety Study (IFS Study). Dermatol Surg 34(3):326–335; discussion 335

    Article  CAS  PubMed  Google Scholar 

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Rzany, B. (2014). Overview on Injectable Fillers: Efficacy and Safety. In: Injectable Fillers in Aesthetic Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45125-6_1

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