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Boron Compounds: New Candidates for Boron Carriers in BNCT

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Neutron Capture Therapy

Abstract

The high accumulation and selective delivery of 10B into the tumor tissue are the most important requirements to achieve efficient neutron capture therapy for cancer. So far, two boron compounds, sodium mercaptoundecahydrododecaborate (Na 102 B12H11SH; Na 102 BSH) and L-p-boronophenylalanine (L-10BPA), have been clinically utilized for the treatment of patients with malignant brain tumors and malignant melanoma. Recently, BNCT has been applied to various cancers, including head and neck cancer, lung cancer, hepatoma, chest wall cancer, and mesothelioma. Therefore, the development of new boron carriers is one of the most important issues that should be resolved to extend the application of BNCT to various cancers. In the last decade, boron carrier development has taken two directions: small boron molecules and boron-conjugated biological complexes. Unlike approaches using pharmaceuticals, boron carriers require high tumor selectivity and should be essentially nontoxic. Therefore, the latter approach has become one of the recent trends to accumulate a large amount of 10B in tumor tissues. In this review, new and promising candidates for boron carriers developed in the last 10 years are summarized.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1, Mejiro, Toshima-ku, Tokyo, 171-8588, Japan

    Hiroyuki Nakamura

  2. Graduate School of Agriculture and Life Sciences, Osaka Prefecture University, Osaka, Japan

    Mitsunori Kirihata

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  1. Hiroyuki Nakamura
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  2. Mitsunori Kirihata
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Correspondence to Hiroyuki Nakamura .

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Editors and Affiliations

  1. Zentrum für Konservative Onkologie, Klinik für Strahlentherapie, Univ.Klinikum Essen, Hufelandstr. 55, Essen, 45122, Germany

    Wolfgang Sauerwein

  2. Philipps-University Marburg, Department of Radiation Oncology, University Hospital Marburg,, Baldingerstrasse 1, Marburg, 35043, Germany

    Andrea Wittig

  3. Joint Research Centre, Institute for Engergy, European Commission, Westerduinweg 3, LE Petten, 1755, Netherlands

    Raymond Moss

  4. , Department of Neurosurgery, Kagawa National Children's Hospital, Zentsuji-cho 2603, Zentsuji, 765-8501, Kagawa, Japan

    Yoshinobu Nakagawa

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Nakamura, H., Kirihata, M. (2012). Boron Compounds: New Candidates for Boron Carriers in BNCT. In: Sauerwein, W., Wittig, A., Moss, R., Nakagawa, Y. (eds) Neutron Capture Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31334-9_7

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