Abstract
Diffusion Magnetic Resonance Imaging (MRI) is used to (non-invasively) study neuronal fibers in the brain white matter. Reconstructing fiber paths from such data (tractography problem) is relevant in particular to study the connectivity between two given cerebral regions. By considering the fiber paths between two given areas as geodesics of a suitable well-posed optimal control problem (related to optimal mass transportation), we are able to provide a quantitative criterion to estimate the connectivity between two given cerebral regions, and to recover the actual distribution of neuronal fibers between them.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Agrachev, A., Lee, P.: Optimal transportation under nonholonomic constraints. Trans. Amer. Math. Soc. 361(11), 6019–6047 (2009)
Bardi, M., Capuzzo-Dolcetta, I.: Optimal control and viscosity solutions of Hamilton-Jacobi-Bellman equations. Birkhäuser Boston, Boston (1997)
Bernard, P., Buffoni, B.: Optimal mass transportation and Mather theory. J. Eur. Math. Soc. (JEMS) 9(1), 85–121 (2007)
Clarke, F.H., Ledyaev, Y.S., Stern, R.J., Wolenski, P.R.: Nonsmooth analysis and control theory. Graduate Texts in Mathematics, vol. 178. Springer, New York (1998)
Cannarsa, P., Sinestrari, C.: Semiconcave functions, Hamilton-Jacobi equations, and optimal control. Birkhäuser Boston, Boston (2004)
Pichon, E., Westin, C.-F., Tannenbaum, A.: A Hamilton-Jacobi-Bellman Approach to High Angular Resolution Diffusion Tractography. In: Duncan, J.S., Gerig, G. (eds.) MICCAI 2005. LNCS, vol. 3749, pp. 180–187. Springer, Heidelberg (2005)
Siconolfi, A.: Metric character of Hamilton-Jacobi equations. Trans. Amer. Math. Soc. 355(5), 1987–2009 (2003)
Villani, C.: Topics in optimal transportation. Graduate Studies in Mathematics, vol. 58. American Mathematical Society, Providence (2003)
Villani, C.: Optimal transport old and new. Grundlehren der Mathematischen Wissenschaften, vol. 338. Springer, Berlin (2009)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Marigonda, A., Orlandi, G. (2012). Optimal Mass Transportation-Based Models for Neuronal Fibers. In: Lirkov, I., Margenov, S., Waśniewski, J. (eds) Large-Scale Scientific Computing. LSSC 2011. Lecture Notes in Computer Science, vol 7116. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29843-1_14
Download citation
DOI: https://doi.org/10.1007/978-3-642-29843-1_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-29842-4
Online ISBN: 978-3-642-29843-1
eBook Packages: Computer ScienceComputer Science (R0)