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Bio and Nano Packaging Techniques for Electron Devices pp 427–441Cite as

Biofunctionalization of Surfaces Using Ultrathin Nanoscopic Collagen Matrices

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Abstract

The biofunctionalization of materials creates interfaces on which proteins, cells, or tissues can fulfill native or desired tasks. Here we report how to control the assembly of type I collagen into well-defined nanoscopic matrices of different patterns. Collagen fibrils in these ultrathin (approximately 3 nm) matrices maintained their native structure as observed in vivo. This opens up the possibility to create programmable biofunctionalized matrices using collagen-binding proteins or proteins fused with collagen-binding domains. Applied to eukaryotic cells, these nanostructured matrices can direct cellular processes such as adhesion, orientation and migration.

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Authors and Affiliations

  1. Biotechnology Center, Technische Universität Dresden, 01307, Dresden, Germany

    Jens Friedrichs, Anna Taubenberger, Susanne Wegmann, David A. Cisneros, Clemens Franz & Daniel J. Müller

Authors
  1. Jens Friedrichs
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  2. Anna Taubenberger
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  3. Susanne Wegmann
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  4. David A. Cisneros
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  5. Clemens Franz
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  6. Daniel J. Müller
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Corresponding author

Correspondence to Daniel J. Müller .

Editor information

Editors and Affiliations

  1. Fak. Elektrotechnik, Inst. Festkörperelektronik, TU Dresden, Helmholtzstr. 18, Dresden, 01069, Sachsen, Germany

    Gerald Gerlach

  2. Fak. Elektrotechnik und, Informationstechnik, TU Dresden, Mommsenstr. 13, Dresden, 01069, Sachsen, Germany

    Klaus-Jürgen Wolter

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Friedrichs, J., Taubenberger, A., Wegmann, S., Cisneros, D.A., Franz, C., Müller, D.J. (2012). Biofunctionalization of Surfaces Using Ultrathin Nanoscopic Collagen Matrices. In: Gerlach, G., Wolter, KJ. (eds) Bio and Nano Packaging Techniques for Electron Devices. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28522-6_21

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