Abstract
The kidney regulates the composition of the final urine by modulating the reabsorption and secretion of water and solutes across the specialized epithelium of each nephron segment. This chapter begins with an overview of epithelial barriers, including their permeability properties and main classes of transporters. We then derive the conservation and flux equations that are needed to represent the dynamic exchange of water and solutes across tubular epithelia. Lastly, we describe how to formulate a complete, cell-based model of transport across renal tubules.
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Layton, A.T., Edwards, A. (2014). Transport Across Tubular Epithelia. In: Mathematical Modeling in Renal Physiology. Lecture Notes on Mathematical Modelling in the Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27367-4_8
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DOI: https://doi.org/10.1007/978-3-642-27367-4_8
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