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How to Knock Out Feedback Circuits in Gene Networks?

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Pattern Formation in Morphogenesis

Part of the book series: Springer Proceedings in Mathematics ((PROM,volume 15))

Abstract

The development of living organisms involves the successive activation of several gene networks. It is often known if activation or inhibition of a given gene occurs in these networks, but their global dynamic remains poorly understood. It is thus important to understand the function of motives contained in such a network, and for this one has to be able to perform knock out experiments.

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References

  1. Kaufman M, Soulé C, Thomas R (2007) A new necessary condition on interaction graphs for multistationarity. J Theor Biol 248:675–685

    Article  Google Scholar 

  2. Richard A (2010) Negative circuits and sustained oscillations in asynchronous automata networks. Adv Appl Math 44:378–392

    Article  MathSciNet  MATH  Google Scholar 

  3. Robert F (1986) Discrete iterations: a metric study, vol 6, Series in computational mathematics. Springer, Berlin/Heidelberg/New York

    Book  MATH  Google Scholar 

  4. Soulé C (2006) Mathematical approaches to differentiation and gene regulation. C R Paris Biol 329:13–20

    Google Scholar 

  5. Karp RM (1972) Reducibility among combinatorial problems. In: Miller RE, Thatcher JW (eds) Complexity of computer computations. Plenum, New York, pp 85–103

    Chapter  Google Scholar 

  6. Gruber H (2011) Bounding the feedback vertex number of digraphs in terms of vertex degrees. Discrete Appl Math 159(8):872–875

    Article  MathSciNet  MATH  Google Scholar 

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Correspondence to C. Soulé .

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© 2013 Springer-Verlag Berlin Heidelberg

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Gruber, H., Richard, A., Soulé, C. (2013). How to Knock Out Feedback Circuits in Gene Networks?. In: Capasso, V., Gromov, M., Harel-Bellan, A., Morozova, N., Pritchard, L. (eds) Pattern Formation in Morphogenesis. Springer Proceedings in Mathematics, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20164-6_14

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