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Enantioselective Catalysis with Structurally Tunable Immobilized Catalysts

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Book cover Asymmetric Catalysis from a Chinese Perspective

Part of the book series: Topics in Organometallic Chemistry ((TOPORGAN,volume 36))

Abstract

Immobilization of a chiral homogeneous catalyst can in principle ­facilitate its separation and recycling, and therefore is of considerable interest to both academia and industry. A number of methods have been developed for the immobilization of chiral catalysts, typically including using inert organic or inorganic materials as supports. However, most of the classical immobilized catalysts suffered from inferior catalytic properties to their homogeneous counterparts due to the poor accessibility, random anchoring, or disturbed geometry of the active sites in the solid matrix. In this chapter, we present the progress made in the immobilization of chiral catalysts by focusing on core-functionalized dendrimers in asymmetric catalysis, asymmetric catalysis in nanopores of mesoporous materials, and self-supported chiral catalysts for asymmetric reactions. All the three types of immobilized catalysts possess relatively well-defined structures together with a tunable chiral environment around the catalytically active centers. Representative examples selected from the researches mostly reported by Chinese chemists have demonstrated the high efficiencies and enantioselectivities of these immobilized catalysts. The impacts of supports, such as isolation or confinement effect, on the catalysis will be discussed with emphasis on their application in enantioselective synthesis.

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Acknowledgments

We are grateful for the financial support from the National Natural Science Foundation of China (20973178, 20821002, 20632060), National Basic Research Program of China (No. 2010CB833300 and 2009ZX09501-017), and Chinese Academy of Sciences.

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Authors and Affiliations

  1. Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing, 100190, P.R. China

    Qing-Hua Fan & Kuiling Ding

  2. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, P.R. China

    Qing-Hua Fan & Kuiling Ding

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  1. Qing-Hua Fan
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  2. Kuiling Ding
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Correspondence to Kuiling Ding .

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Editors and Affiliations

  1. Shanghai Institute of Organic Chemistry, State Key Laboratory of Organometallic, Chinese Academy of Sciences, Fenglin Lu 354, Shanghai, 200032, China, People's Republic

    Shengming Ma

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Fan, QH., Ding, K. (2011). Enantioselective Catalysis with Structurally Tunable Immobilized Catalysts. In: Ma, S. (eds) Asymmetric Catalysis from a Chinese Perspective. Topics in Organometallic Chemistry, vol 36. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19472-6_7

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