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Chronic Inflammation and Hepatocellular Carcinoma

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Inflammation and Gastrointestinal Cancers

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 185))

Abstract

Hepatocellular carcinoma (HCC) invariably develops within a setting of chronic inflammation caused by either hepatotropic viruses, toxins, metabolic liver disease or autoimmunity. Mechanisms that link these two processes are not completely understood, but transcription factors of the NF-κB family and signal transducer and activator of transcription 3 (STAT3), cytokines such as IL-6 and IL-1α and ligands of the epidermal growth factor receptor (EGFR) family are clearly pivotal players. HCC may have its origins in either hepatocytes or hepatic progenitor cells (HPCs), and HCCs, like other solid tumours appear to be sustained by a minority population of cancer stem cells.

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Authors and Affiliations

  1. Centre for Diabetes, Barts and The London School of Medicine and Dentistry, BICMS, 4 Newark Street, London, E1 2AT, UK

    Malcolm R. Alison & Wey-Ran Lin

  2. Division of Cancer Studies, King’s College London, London, UK

    Linda J. Nicholson

  3. Chang Gung Memorial Hospital, Chang Gung University College, Taipei, Taiwan

    Wey-Ran Lin

Authors
  1. Malcolm R. Alison
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  2. Linda J. Nicholson
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  3. Wey-Ran Lin
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Corresponding author

Correspondence to Malcolm R. Alison .

Editor information

Editors and Affiliations

  1. Leicester Royal Infirmary, Dept. Cancer Studies and, University of Leicester, Windsor Building, Level 4, Leicester, LE1 5WW, United Kingdom

    Janusz A. Z. Jankowski

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Alison, M.R., Nicholson, L.J., Lin, WR. (2011). Chronic Inflammation and Hepatocellular Carcinoma. In: Jankowski, J. (eds) Inflammation and Gastrointestinal Cancers. Recent Results in Cancer Research, vol 185. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03503-6_8

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  • DOI: https://doi.org/10.1007/978-3-642-03503-6_8

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-03502-9

  • Online ISBN: 978-3-642-03503-6

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