Nanotechnology Based Delivery of Nutraceuticals

Surve, Dhanashree Hemant; Paul, Atish Tulsiram; Jindal, Anil B.

doi:10.1007/978-3-319-98708-8_3

Dhanashree Hemant Surve⁷,
Atish Tulsiram Paul⁷ &
Anil B. Jindal⁷

Part of the book series: Environmental Chemistry for a Sustainable World ((ECSW,volume 21))

861 Accesses
4 Citations

Abstract

With the growing worldwide population, there is increase in prevalence of various diseases like cancer (0.338%), hyperlipidemia (39%), hypertension (44.5%), infectious disease (17 million/ annum), diabetes (18.4%), obesity (25.9%) and osteoporosis (200 million/ annum). Nutraceutical seek their application in prophylaxis and cure of these diseases for instance, coenzyme Q-10, polyphenols, isoflavone, flavones, carotenoid, isocyanidine for treatment of cancer and other life threatening diseases, elements like zinc as prophylactic treatment to maintain metabolism, calcium and magnesium to maintain bone health, Selenium as an anti-oxidant, vitamin D for osteoporosis, vitamin E & C as anti-oxidant for prevention of cancer and vitamin B-complex for proper functioning of nervous system. However, nutraceuticals have certain limitations including poor solubility, absorption and bioavailability, chemical instability and higher first pass metabolism which can be overcome by nano-delivery of nutraceutical.

Various formulation technologies like submicron emulsion, lipid nanoparticles, liposomes, polymeric micelles, polymeric nanoparticles, inorganic nanoparticles and nanocomposites are currently under thorough research in order to eliminate the above said limitations of nutraceuticals. Submicron emulsion enhances solubility, half-life, bioavailability of bioactives along with reduced gastric irritation. Self-nanoemulsifying or self-microemulsifying drug delivery system has a property to reduce poor palatability, hydrolysis of bioactive and large amount of water and lymphatic uptake of bioactive causing increased bioavailability. Lipid nanoparticles due to their smaller size and lipophilicity could provide advantages of enhanced permeation of bioactives through blood brain barrier and improved bioavailability. Liposomal delivery system is useful to prevent the sensitive bioactives from oxidation, light and moisture. It can serve as unique system to deliver both hydrophilic and lipophilic bioactive. Highly potent anti-cancer bioactive possess reduced bioavailability and inability to deliver at specific site. Dendrimer and inorganic nanoparticles can be utilized for targeting such bioactive and sustained release. Polymeric micelles are stable compared to submicron emulsion and are useful for triggered release of bioactive and protection of bioactive from enzymatic degradation. Polymeric nanoparticles derived from natural source like zein, β-lactoglobulin, β-casein and nanodiamond can be used to deliver bioactives in controlled manner, protection from harsh acidic environment and reduced toxicity.

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Abbreviations

ANOVA:: Analysis of variance
CMC:: Critical micelle concentration
CO Q-10:: Coenzyme Q-10
EGFR:: Endothelial growth factor receptor
GIT:: Gastrointestinal tract
GMS:: Glyceryl monostearate
HA:: Hyaluronic acid
HAuCl₄:: Gold hydrogen chloride
LNCaP:: Human prostate cancer cell lines
LNP:: Lipid nanoparticles
NLC:: Nanostructured lipid carrier
NLC-H1299:: Non-small cell lung cancer
o/w:: Oil in water
PDI:: Polydispersity index
PSMA:: Prostate specific monoclonal antibody
PUFA:: Polyunsaturated fatty acid
SEDDS:: Self-emulsifying drug delivery system
SMEDDS:: Self-microemulsifying drug delivery system
SNEDDS:: Self-nanoemulsifying drug delivery system
s-SNEDDS:: Solid-SNEDDS
SiRNA:: Small interfering RNA
TAMRA-TAT:: 5-(and 6)-carboxytetramethylrhodamine labelled HIV transactivator protein TAT

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Department of Pharmacy, Birla Institute of Technology & Science, Pilani, Pilani Campus, Jhunjhunu, Rajasthan, India
Dhanashree Hemant Surve, Atish Tulsiram Paul & Anil B. Jindal

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Dhanashree Hemant Surve
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Atish Tulsiram Paul
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Anil B. Jindal
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Institute of Engineering and Technology, Dr. A.P.J. Abdul Kalam Technical University Uttar Pradesh, Lucknow, Uttar Pradesh, India
Nandita Dasgupta
Faculty of Engineering & The Built Environment, University of Johannesburg, Johannesburg, Gauteng, India
Shivendu Ranjan
Aix Marseille Univ, CNRS, IRD, INRA, Coll France, CEREGE, Aix en Provence, France
Eric Lichtfouse

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Surve, D.H., Paul, A.T., Jindal, A.B. (2019). Nanotechnology Based Delivery of Nutraceuticals. In: Dasgupta, N., Ranjan, S., Lichtfouse, E. (eds) Environmental Nanotechnology. Environmental Chemistry for a Sustainable World, vol 21. Springer, Cham. https://doi.org/10.1007/978-3-319-98708-8_3

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Published: 23 November 2018
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