Abstract
Clostridium difficile colitis should be suspected in patients with watery foul-smelling diarrhea who have recently been hospitalized or exposed to antibiotics. Stool should be evaluated for C. difficile toxin to establish the diagnosis. Abdominal exam, white blood cells (WBC), and renal function should be used to determine the severity of infection. Patients with fulminant colitis, such as signs of systemic toxicity, should have a computed tomography (CT) scan to determine the extent of inflammation and dilation of the colon. If the colon is perforated, a total abdominal colectomy with end ileostomy should be performed. Management of mild disease is with metronidazole and per oral (PO) vancomycin for severe disease. Severe-complicated disease is treated with a combination of vancomycin PO and metronidazole IV and vancomycin enemas if ileus is suspected. Fecal transplant should be considered in patients with relapsing or refractory disease.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Ananthakrishnan AN. Detecting and treating Clostridium difficile infections in patients with inflammatory bowel disease. Gastroenterol Clin N Am. 2012;41(2):339–53.
Surawicz CM, Brandt LJ, Binion DG, Ananthakrishnan AN, Curry SR, Gilligan PH, et al. Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections. Am J Gastroenterol. 2013;108(4):478–98. quiz 99
Butala P, Divino CM. Surgical aspects of fulminant Clostridium difficile colitis. Am J Surg. 2010;200(1):131–5.
Kaiser AM, Hogen R, Bordeianou L, Alavi K, Wise PE, Sudan R, et al. Clostridium difficile infection from a surgical perspective. J Gastrointest Surg. 2015;19(7):1363–77.
Katzman M. Antibiotic therapy for Clostridium difficile infection. Semin Colon Rectal Surg. 2014;25(3):143–9.
Lee CH, Steiner T, Petrof EO, Smieja M, Roscoe D, Nematallah A, et al. Frozen vs fresh fecal microbiota transplantation and clinical resolution of diarrhea in patients with recurrent Clostridium difficile infection: a randomized clinical trial. JAMA. 2016;315(2):142–9.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Crowell, K.T., Messaris, E. (2019). Clostridium difficile Colitis. In: Docimo Jr., S., Pauli, E. (eds) Clinical Algorithms in General Surgery . Springer, Cham. https://doi.org/10.1007/978-3-319-98497-1_63
Download citation
DOI: https://doi.org/10.1007/978-3-319-98497-1_63
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-98496-4
Online ISBN: 978-3-319-98497-1
eBook Packages: MedicineMedicine (R0)