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Management of VIPoma

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Clinical Algorithms in General Surgery

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Abstract

VIPomas are extremely rare tumors that secrete excessive vasoactive intestinal peptide (VIP). Symptoms include watery diarrhea, flushing, hypotension, and dehydration. Most VIPomas are sporadic but can be associated with multiple endocrine neoplasia type 1 (MEN1). Biochemical evaluation may show hypochloremic, hypokalemic metabolic acidosis. Diagnosis is confirmed with fasting VIP levels >200 pg/ml. Tumors may be localized with cross-sectional imaging with either computed tomography (CT) or magnetic resonance imaging (MRI). VIPomas are usually >2 cm and located in the body or tail of the pancreas. Surgical resection is indicated for isolated disease.

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References

  1. James BC, Aschebrook-Kilfoy B, Cipriani N, Kaplan EL, Angelos P, Grogan RH. The incidence and survival of rare cancers of the thyroid, parathyroid, adrenal, and pancreas. Ann Surg Oncol. 2016;23(2):424–33.

    Article  Google Scholar 

  2. Melmed S, Polonsky KS, Larsen PR, Kronenberg HM. Chapter 38: Gastrointestinal hormones and gut endocrine tumors. In: Williams textbook of endocrinology. 13th ed. Philadelphia: Elsevier; 2016. p. 1701–22.

    Google Scholar 

  3. Feldman M, Friedman LS, Brandt LJ. Chapter 33: Neuroendocrine tumors. In: Sleisenger and Fordtran’s gastrointestinal and liver disease. Philadelphia: Elsevier; 2016. p. 501–41.

    Google Scholar 

  4. Townsend CM Jr, Beauchamp RD, Evers BM, Mattox KL. Chapter 38: Endocrine pancreas. In: Sabiston textbook of surgery. 20th ed. Philadelphia: Elsevier; 2017. p. 941–62.

    Google Scholar 

  5. Jameson JL, De Groot LJ, de Kretser DM, Guidice LC, Grossman AB, Melmed S, Potts JT, Weir GC. Chapter 150: Neuroendocrine tumor syndromes. In: Endocrinology: adult and pediatric. 7th ed. Philadelphia: Elsevier Saunders; 2016. p. 2606–14.

    Google Scholar 

  6. Maxwell JE, O’Dorisio TM, Howe JR. Biochemical diagnosis and preoperative imaging of gastroenteropancreatic neuroendocrine tumors. Surg Oncol Clin N Am. 2016;25(1):171–94.

    Article  Google Scholar 

  7. O’Dorisio TM, Gaginella TS, Mekhjian HS, Rao B, O’Dorisio MS. Somatostatin and analogues in the treatment of VIPoma. Ann N Y Acad Sci. 1988;527:528–35.

    Article  Google Scholar 

  8. Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE. Chapter 71: Cancer of the endocrine system. In: Abeloff’s clinical oncology. 5th ed. Philadelphia: Elsevier; 2014. p. 1112–42.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Surgery, Indiana University, Indianapolis, IN, USA

    Rachel E. Simpson

  2. Department of Surgery, Harvard Medical School, Boston, MA, USA

    Benjamin C. James

  3. Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Benjamin C. James

Authors
  1. Rachel E. Simpson
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  2. Benjamin C. James
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Correspondence to Benjamin C. James .

Editor information

Editors and Affiliations

  1. Department of Surgery, Stony Brook Medicine, Stony Brook, NY, USA

    Salvatore Docimo Jr.

  2. Department of Surgery, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA

    Eric M. Pauli

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Simpson, R.E., James, B.C. (2019). Management of VIPoma. In: Docimo Jr., S., Pauli, E. (eds) Clinical Algorithms in General Surgery . Springer, Cham. https://doi.org/10.1007/978-3-319-98497-1_118

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  • DOI: https://doi.org/10.1007/978-3-319-98497-1_118

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-98496-4

  • Online ISBN: 978-3-319-98497-1

  • eBook Packages: MedicineMedicine (R0)

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