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Extramedullary Haemopoiesis

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Pathology of the Placenta

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Abstract

Blood cell production starts within the yolk sac during the third week of gestation, from where haematopoietic stem cells colonise the umbilical cord and aorta-gonad-mesonephros region and then the liver. By term, the bone marrow is the main site of blood cell production. Extramedullary haemopoiesis (EMH) is defined as blood cell production outside the bone marrow and, in the placenta, it happens within the villous stroma. Prolonged hypoxia and/or anaemia, usually associated with hydrops fetalis, may induce placental EMH, where a central macrophage provides the adequate microenvironment for maturation of the erythroid precursors.

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Authors and Affiliations

  1. Department of Histopathology, Sheffield Children’s NHS Foundation Trust, Sheffield, UK

    Luiz Cesar Peres

  2. University of Sheffield, Sheffield, UK

    Luiz Cesar Peres

Authors
  1. Luiz Cesar Peres
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Correspondence to Luiz Cesar Peres .

Editor information

Editors and Affiliations

  1. Department of Anatomical Pathology, Women’s and Children’s Hospital, North Adelaide, SA, Australia

    T. Yee Khong

  2. Department of Pathology and Laboratory Medicine, National Maternity Hospital, Dublin, Ireland

    Eoghan E. Mooney

  3. Department of Pathology, University Medical Centre Utrecht, Utrecht, The Netherlands

    Peter G. J. Nikkels

  4. Department of Pathology, Oregon Health and Science University, Portland, OR, USA

    Terry K. Morgan

  5. Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

    Sanne J. Gordijn

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Peres, L.C. (2019). Extramedullary Haemopoiesis. In: Khong, T., Mooney, E., Nikkels, P., Morgan, T., Gordijn, S. (eds) Pathology of the Placenta. Springer, Cham. https://doi.org/10.1007/978-3-319-97214-5_22

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  • DOI: https://doi.org/10.1007/978-3-319-97214-5_22

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-97213-8

  • Online ISBN: 978-3-319-97214-5

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