Abstract
Hemostasis is defined as the maintenance of the fluidity of circulating blood while at the same time protecting the organism from life-threatening bleeding at sites of vascular injury. The cell-mediated system of proteolysis of plasma coagulation proteins is essential for the survival of the organism. The hemostatic mechanism has evolved as a complex system in which serine proteases with high specificity assemble on cell membrane receptors in complex with cofactor molecules. They propagate several enzymatic reactions that lead to the formation of a thrombus that stop bleedings. It can be divided into the processes of platelet plug formation, blood coagulation, anticoagulation, and fibrinolysis (Walsh and Ahmad 2002).
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Pepe, A., Guevara, M.G., Tito, F.R. (2018). Potential Use of Plant Proteolytic Enzymes in Hemostasis. In: Guevara, M., Daleo, G. (eds) Biotechnological Applications of Plant Proteolytic Enzymes. Springer, Cham. https://doi.org/10.1007/978-3-319-97132-2_6
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