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Omics in Diabetic Kidney Disease

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Diabetic Nephropathy

Abstract

The sequencing of the human genome has led to a new era of molecular diagnostics through the development of omics sciences that, from genomics to metabolomics, may now allow to analyze thousands of genes, transcripts, proteins, and metabolites and correlate their expression to the clinical phenotype of many disease conditions. It is a shared expectation that this huge amount of information will enable, in the coming years, the development of new and more accurate tools for personalized medicine. In this chapter we will describe the main omics fields: genomics, epigenomics, transcriptomics, proteomics, and metabolomics. A brief introduction will cover the main discoveries that contributed to the evolution of each field, and then the reader will be guided through the most popular techniques and methods used to characterize and study the molecules within each omics. Finally, some among the main omics studies in diabetic kidney disease and diabetic nephropathy (DN) will be presented and discussed. In the final part, we will analyze the main drawbacks of current approaches and the actions needed to improve the reliability of the data generated through omics in order to realize new point-of-care tests applicable for the real-time health status monitoring.

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Acknowledgments

We want like to thank Dr. Eustacchio Montemurno for the realization of figures of this manuscript.

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Authors and Affiliations

  1. Division of Nephrology, Department of Emergency and Organ Transplantation, University of Bari “Aldo Moro”, Bari, Italy

    Massimo Papale, Francesca Conserva, Paola Pontrelli & Loreto Gesualdo

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  1. Massimo Papale
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  2. Francesca Conserva
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  3. Paola Pontrelli
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  4. Loreto Gesualdo
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Correspondence to Loreto Gesualdo .

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Editors and Affiliations

  1. Department of Pathology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands

    Joris J. Roelofs

  2. Department of Internal Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands

    Liffert Vogt

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Papale, M., Conserva, F., Pontrelli, P., Gesualdo, L. (2019). Omics in Diabetic Kidney Disease. In: Roelofs, J., Vogt, L. (eds) Diabetic Nephropathy. Springer, Cham. https://doi.org/10.1007/978-3-319-93521-8_28

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