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CIRI After Early Recanalization

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Cerebral Ischemic Reperfusion Injuries (CIRI)

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

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Abstract

Even with rapid reperfusion therapy for acute ischemic stroke, there is still a potential risk of clinical deterioration, such as cerebral hemorrhage, infarct growth or brain edema after early recanalization, which is so-called “reperfusion injury”. Blood-brain barrier (BBB) damage, inflammatory responses and leukocyte recruitment are believed as main pathophysiological mechanisms. With the development of neuroimage, several novel neuroimaging markers had been reported. Hyperintense acute reperfusion marker (HARM) and quantitative methods including Patlak algorithm, relative recirculation (rR) on enhanced neuroimage can evaluate the damage of BBB, which may induce cerebral hemorrhage. Postischemic hyperperfusion and “no-reflow phenomenon”, which correlate with infarct growth, are observed on perfusion image. Ischemic conditioning therapy, immunosuppressive agents and hypothermia treatment may have potential therapeutic values in future.

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Author information

Authors and Affiliations

  1. Department of Neurology, School of Medicine, The 2nd Affiliated Hospital of Zhejiang University, Hangzhou, China

    Qingmeng Chen & Min Lou

Authors
  1. Qingmeng Chen
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  2. Min Lou
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Editor information

Editors and Affiliations

  1. Department of Vascular Neurosurgery, PLA Rocket Force General Hospital, Beijing, China

    Weijian Jiang

  2. Department of Neurology, University of California Irvine, Irvine, California, USA

    Wengui Yu

  3. Department of Neurosurgery, Tangdu Hospital of Air Force Medical University, Xi’an, China

    Yan Qu

  4. Department of Neurosurgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

    Zhongsong Shi

  5. Department of Neurology, The First Affiliated Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

    Benyan Luo

  6. Department of Anesthesiology, Loma Linda University, Loma Linda, California, USA

    John H. Zhang

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Chen, Q., Lou, M. (2018). CIRI After Early Recanalization. In: Jiang, W., Yu, W., Qu, Y., Shi, Z., Luo, B., Zhang, J. (eds) Cerebral Ischemic Reperfusion Injuries (CIRI). Springer Series in Translational Stroke Research. Springer, Cham. https://doi.org/10.1007/978-3-319-90194-7_4

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  • DOI: https://doi.org/10.1007/978-3-319-90194-7_4

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-90193-0

  • Online ISBN: 978-3-319-90194-7

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