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Ischemia/Reperfusion Damage in Diabetic Stroke

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Cerebral Ischemic Reperfusion Injuries (CIRI)

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

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Abstract

Stroke is a leading cause of death and long-term disability. Patients with diabetes mellitus suffer from an increased risk of cardiovascular and cerebrovascular diseases including ischemic stroke. Diabetic stroke patients sustain worse neurological deficits and battle high mortality rates. Diabetes triggers a detrimental pathophysiological cascade resulting in severe vascular dysfunction and I/R injury which result in poor outcome after stroke in this population. The various aspects of diabetic stroke induced vascular and reperfusion damage and the underlying mechanisms are discussed in this chapter.

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Acknowledgements

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Sources of funding This work was supported by National Institute of Neurological Disorders and Stroke R01 NS083078-01A1 (JC) and RO1 NS099030-01 (JC) and R01NS097747 (QJ/JC).

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Authors and Affiliations

  1. Neurology, Henry Ford Hospital, Detroit, MI, USA

    Poornima Venkat, Michael Chopp & Jieli Chen

  2. Department of Physics, Oakland University, Rochester, MI, USA

    Michael Chopp

  3. Neurological & Gerontology Institute, Tianjin Medical University General Hospital, Tianjin, China

    Jieli Chen

  4. Neurology Research, Henry Ford Hospital, Detroit, MI, USA

    Jieli Chen

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  1. Poornima Venkat
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  2. Michael Chopp
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  3. Jieli Chen
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Correspondence to Jieli Chen .

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Editors and Affiliations

  1. Department of Vascular Neurosurgery, PLA Rocket Force General Hospital, Beijing, China

    Weijian Jiang

  2. Department of Neurology, University of California Irvine, Irvine, California, USA

    Wengui Yu

  3. Department of Neurosurgery, Tangdu Hospital of Air Force Medical University, Xi’an, China

    Yan Qu

  4. Department of Neurosurgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

    Zhongsong Shi

  5. Department of Neurology, The First Affiliated Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

    Benyan Luo

  6. Department of Anesthesiology, Loma Linda University, Loma Linda, California, USA

    John H. Zhang

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Venkat, P., Chopp, M., Chen, J. (2018). Ischemia/Reperfusion Damage in Diabetic Stroke. In: Jiang, W., Yu, W., Qu, Y., Shi, Z., Luo, B., Zhang, J. (eds) Cerebral Ischemic Reperfusion Injuries (CIRI). Springer Series in Translational Stroke Research. Springer, Cham. https://doi.org/10.1007/978-3-319-90194-7_11

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