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Combination Therapy

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Evidence-Based Psoriasis

Part of the book series: Updates in Clinical Dermatology ((UCD))

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Abstract

Psoriasis is a chronic inflammatory skin disease with a remitting and relapsing course. Long-term remission can be difficult to achieve regardless of severity of psoriasis. Using two or more therapies with varying mechanisms of action and safety profiles is often necessary to maintain adequate disease control while minimizing toxicity of treatments. Choosing a combination regimen that maximizes safety and efficacy, while at the same time considers patient usability and compliance, can be difficult. Presently, numerous treatment options are available for the treatment of psoriasis including topical agents, phototherapy, oral systemic agents, and biologics, with many more therapeutic agents in the pipeline. With the increasing number of available therapies, there are many opportunities to combine various therapies. It is crucial for clinicians to carefully consider the fine balance between safety and efficacy when combining various therapeutic agents and utilize strategies such as rotational therapy and sequential therapy when appropriate. This chapter will review various combination therapy strategies for the treatment of psoriasis.

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Authors and Affiliations

  1. Department of Dermatology, Psoriasis and Skin Treatment Center, University of California San Francisco, San Francisco, CA, USA

    Mio Nakamura & John Koo

  2. Department of Dermatology, UCSF Psoriasis Center, University of California San Francisco, San Francisco, CA, USA

    Caleb Jeon

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  1. Mio Nakamura
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  2. Caleb Jeon
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Correspondence to Mio Nakamura .

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  1. Department of Dermatology UCSF Psoriasis Center, University of California, San Francisco, California, USA

    Tina Bhutani

  2. Department of Dermatology UCSF Psoriasis Center, University of California, San Francisco, California, USA

    Wilson Liao

  3. Department of Dermatology Psoriasis and Skin Treatment Center, University of California, San Francisco, California, USA

    Mio Nakamura

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Nakamura, M., Jeon, C., Koo, J. (2018). Combination Therapy. In: Bhutani, T., Liao, W., Nakamura, M. (eds) Evidence-Based Psoriasis. Updates in Clinical Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-90107-7_7

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