Abstract
Tuberculosis (TB) is the most common infectious disease in the world, with more than one million new cases and 210,000 deaths in children annually (Murray et al., Lancet 384, 1005–70, 2014). Over two billion people are infected with Mycobacterium tuberculosis, and rates of TB disease are increasing among women of child-bearing age in developing countries (Hageman, J Perinatol. 18, 389–94, 1998; Margono et al. Obstet Gynecol. 83, 911–4, 1994; Starke, Clin Perinatol. 24, 107–27, 1997). Although TB infection and disease are very common, perinatally acquired infection and disease are rare and incompletely understood (Peker et al. Tuberk Toraks. 58, 93–6, 2010). Perinatally transmitted TB can be acquired vertically during the intrauterine period (congenital TB) or shortly after birth (postnatal) through exposure to someone with contagious pulmonary disease (Starke, Clin Perinatol. 24, 107–27, 1997; Malhamé et al. PLoS One 11, e0154825, 2016). Differentiating congenital and postnatally acquired TB is only important from an epidemiological standpoint as their clinical presentations, management, and prognosis are indistinguishable (Singh, J Trop Pediatr. 53, 135–8, 2007). Distinguishing TB infection from disease is important in determining management. If a person has a positive tuberculin skin test (TST) or interferon-gamma release assay (IGRA) with a normal CXR and is asymptomatic, he/she is considered to have TB infection. A person who has a positive TST or IGRA with an abnormal CXR or symptoms consistent with TB such as fever, cough, or weight loss is considered to have TB disease.
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References
Murray CJ, Ortblad KF, Guinovart C, et al. Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990--2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384:1005–70.
Hageman JR. Congenital and perinatal tuberculosis: discussion of difficult issues in diagnosis and management. J Perinatol. 1998;18:389–94.
Margono F, Mroueh J, Garely A, White D, Duerr A, Minkoff HL. Resurgence of active tuberculosis among pregnant women. Obstet Gynecol. 1994;83:911–4.
Starke JR. Tuberculosis. An old disease but a new threat to the mother, fetus, and neonate. Clin Perinatol. 1997;24:107–27.
Peker E, Bozdoğan E, Doğan M. A rare tuberculosis form: congenital tuberculosis. Tuberk Toraks. 2010;58:93–6.
Malhamé I, Cormier M, Sugarman J, Schwartzman K. Latent Tuberculosis in Pregnancy: A Systematic Review. PLoS One. 2016;11:e0154825.
Singh M, Kothur K, Dayal D, Kusuma S. Perinatal tuberculosis a case series. J Trop Pediatr. 2007;53:135–8.
Saramba MI, Zhao D. A perspective of the diagnosis and management of congenital tuberculosis. J Pathog. 2016;2016:8623825.
Peng W, Yang J, Liu E. Analysis of 170 cases of congenital TB reported in the literature between 1946 and 2009. Pediatr Pulmonol. 2011;46:1215–24.
Ormerod P. Tuberculosis in pregnancy and the puerperium. Thorax. 2001;56:494–9.
Espiritu N, Aguirre L, Jave O, Sanchez L, Kirwan DE, Gilman RH. Congenital transmission of multidrug-resistant tuberculosis. Am J Trop Med Hyg. 2014;91:92–5.
Sagar T, Gupta K, Rani M, Kaur IR. Disseminated tuberculosis in a newborn infant. J Family Med Prim Care. 2016;5:695.
Khorsand Zak H, Mafinezhad S, Haghbin A. Congenital tuberculosis: a newborn case report with rare manifestation. Iran Red Crescent Med J. 2016;18:e23572.
Mittal H, Das S, Faridi MM. Management of newborn infant born to mother suffering from tuberculosis: current recommendations & gaps in knowledge. Indian J Med Res. 2014;140:32–9.
Cantwell MF, Shehab ZM, Costello AM, et al. Brief report: congenital tuberculosis. N Engl J Med. 1994;330:1051–4.
Vallejo JG, Starke JR. Tuberculosis and pregnancy. Clin Chest Med. 1992;13:693–707.
Hageman J, Shulman S, Schreiber M, Luck S, Yogev R. Congenital tuberculosis: critical reappraisal of clinical findings and diagnostic procedures. Pediatrics. 1980;66:980–4.
Hatzistamatiou Z, Kaleyias J, Ikonomidou U, Papathoma E, Prifti E, Kostalos C. Congenital tuberculous lymphadenitis in a preterm infant in Greece. Acta Paediatr. 2003;92:392–4.
Ng PC, Hiu J, Fok TF, Nelson EAS, Cheung KL, Wong W. Isolated congenital tuberculosis otitis in a preterm infant. Acta Paediatr. 1995;84:955–6.
Aelami MH, Qhodsi Rad MA, Sasan MS, Ghazvini K. Congenital tuberculosis presenting as ascites. Arch Iran Med. 2011;14:209–10.
Vadivelu S, Effendi S, Starke JR, Luerssen TG, Jea A. A review of the neurological and neurosurgical implications of tuberculosis in children. Clin Pediatr. 2013;52:1135–43.
Raj P, Sarin YK. Congenital tuberculosis in a neonate: a diagnostic dilemma. J Neonatal Surg. 2014;3:49.
Berk DR, Sylvester KG. Congenital tuberculosis presenting as progressive liver dysfunction. Pediatr Infect Dis J. 2004;23:78–80.
Pejham S, Altman R, Li KI, Munoz JL. Congenital tuberculosis with facial nerve palsy. Pediatr Infect Dis J. 2002;21:1085–6.
Kumar A, Ghosh SB, Varshney MK, Trikha V, Khan SA. Congenital spinal tuberculosis associated with asymptomatic endometrial tuberculosis: a rare case report. Joint Bone Spine. 2008;75:353–5.
Smith KC. Congenital tuberculosis: a rare manifestation of a common infection. Curr Opin Infect Dis. 2002;15:269–74.
Stahelin-Massik J, Carrel T, Duppenthaler A, Zeilinger G, Gnehm HE. Congenital tuberculosis in a premature infant. Swiss Med Wkly. 2002;132:598.
Whittaker E, Kampmann B. Perinatal tuberculosis: new challenges in the diagnosis and treatment of tuberculosis in infants and the newborn. Early Hum Dev. 2008;84:795–9.
Miller F. Tuberculosis in children. Evolution-control-treatment. Harcourt-Brace: San Diego; 1963.
Dooley KE, Chaisson RE. Tuberculosis and diabetes mellitus: convergence of two epidemics. Lancet Infect Dis. 2009;9:737–46.
Kwan CK, Ernst JD. HIV and tuberculosis: a deadly human syndemic. Clin Microbiol Rev. 2011;24:351–76.
Beitzke H. Über die angeborene tuberkulöse Infektion. Ergeb Ges Tuberk Forsch. 1935;7:1–30.
Al-Zamel FA. Detection and diagnosis of Mycobacterium tuberculosis. Expert Rev Anti Infect Ther. 2009;7:1099–108.
Dunn JJ, Starke JR, Revell PA. Laboratory diagnosis of Mycobacterium tuberculosis infection and disease in children. J Clin Microbiol. 2016;54:1434–41.
Denkinger CM, Schumacher SG, Boehme CC, Dendukuri N, Pai M, Steingart KR. Xpert MTB/RIF assay for the diagnosis of extrapulmonary tuberculosis: a systematic review and meta-analysis. Eur Respir J. 2014;44:435–46.
Xpert MTB/RIF implementation manual: technical and operational ‘how-to’; practical considerations. Geneva: World Health Organization; 2014.
Ray M, Dixit A, Vaipei K, Singhi PD. Congenital tuberculosis. Indian Pediatr. 2002;39:1167–8.
Hanekom W. Tuberculosis. In: Remington and Klein’s infectious diseases of the fetus and newborn infant. 8th ed. Philadelphia: Elsevier; 2016.
Mlotha R, Waterhouse D, Dzinjalamala F, et al. Pharmacokinetics of anti-TB drugs in Malawian children: reconsidering the role of ethambutol. J Antimicrob Chemother. 2015;70:1798–803.
Patel S, DeSantis ERH. Treatment of congenital tuberculosis. Am J Health Syst Pharm. 2008;65:2027–31.
Skevaki CL, Kafetzis DA. Tuberculosis in neonates and infants: epidemiology, pathogenesis, clinical manifestations, diagnosis, and management issues. Paediatr Drugs. 2005;7:219–34.
Ghosh K, Chowdhury JR. Tuberculosis and female reproductive health. J Postgrad Med. 2011;57:307.
Red Book. Report of the Committee on Infectious Diseases, Elk grove Village: American Academy of Pediatrics; 2015.
Lamounier JA, Moulin ZS, Xavier CC. Recommendations for breastfeeding during maternal infections. J Pediatr (Rio J). 2004;80:s181–8.
Centers for Disease Control and Prevention. The role of BCG vaccine in the prevention and control of tuberculosis in the United States-a joint statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices. Morb Mortal Wkly Rep. 1996;45:1–27.
Abubakar I, Pimpin L, Ariti C, et al. Systematic review and meta-analysis of the current evidence on the duration of protection by bacillus Calmette-Guérin vaccination against tuberculosis. Health Technol Assess. 2013;17:1.
Roy A, Eisenhut M, Harris RJ, et al. Effect of BCG vaccination against Mycobacterium tuberculosis infection in children: systematic review and meta-analysis. BMJ. 2014;349:4643.
Geiter LJ, Huebner RE, Lanner AH, Villarino ME. The role of BCG vaccine in the prevention and control of tuberculosis in the United States; a joint statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices; 1995.
Grisaru-Soen G, Savyon M, Sadot E, et al. Congenital tuberculosis and management of exposure in neonatal and pediatric intensive care units. Int J Tuberc Lung Dis. 2014;18:1062–5.
Laartz BW, Narvarte HJ, Holt D, Larkin JA, Pomputius WF. Congenital tuberculosis and management of exposures in a neonatal intensive care unit. Infect Control Hosp Epidemiol. 2002;23:573–9.
Crockett M, King SM, Kitai I, et al. Nosocomial transmission of congenital tuberculosis in a neonatal intensive care unit. Clin Infect Dis. 2004;39:1719–23.
Lee LH, LeVea CM, Graman PS. Congenital tuberculosis in a neonatal intensive care unit: case report, epidemiological investigation, and management of exposures. Clin Infect Dis. 1998;27:474–7.
Winters A, Agerton TB, Driver CR, Trieu L, O’Flaherty T, Munsiff SS. Congenital tuberculosis and management of exposure in three neonatal intensive care units. Int J Tuberc Lung Dis. 2010;14:1641–3.
Reynolds DL, Gillis F, Kitai I, Deamond SL, Silverman M, King SM, et al. Transmission of Mycobacterium tuberculosis from an infant. Int J Tuberc Lung Dis. 2006;10:1051–6.
Jensen PA, Lambert LA, Iademarco MF, Ridzon R. Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care settings, 2005. MMWR Recomm Rep. 2005;54:1–141.
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Lamb, G.S., Starke, J.R. (2018). Tuberculosis in the Neonate. In: Cantey, J. (eds) Neonatal Infections. Springer, Cham. https://doi.org/10.1007/978-3-319-90038-4_22
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DOI: https://doi.org/10.1007/978-3-319-90038-4_22
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