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Implication of HSP70 in the Pathogenesis of Gastric Cancer

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HSP70 in Human Diseases and Disorders

Part of the book series: Heat Shock Proteins ((HESP,volume 14))

Abstract

Gastric cancer is the third most common cause of cancer linked mortality in the world. Despite recent advances in treatment regimes, effective prognosis and diagnosis of GC is still a formidable task as the disease is asymptomatic in early stages. Heat Shock Proteins (HSP) constitute a class of ubiquitous and highly conserved proteins that show differential expression during different stresses including cancer. HSP70, an important member of the HSP family, regulate various biological processes like protein folding and degradation, apoptosis, and angiogenesis related with tumorigenesis. Differential expression of HSP70 has been explored in tumor versus normal tissues. Upregualtion of HSP70 has been validated in advanced stages making it a future potential prognostic marker in GC. Infection with Helicobacter pylori, a major causative agent of GC, is known to communicate with HSP70 and downregulate its expression. Genetic polymorphism has been correlated with susceptibility to many diseases and association of HSP70 polymorphism in GC is no exception. This chapter deals with various functional roles of HSP70 and its implication in tumorigenesis, particularly gastric cancer.

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Abbreviations

GC:

gastric cancer

H. pylori :

Helicobacter pylori

HSF:

heat shock factor

HSP:

heat shock proteins

IHC:

immunohistochemistry

kDA:

kilo dalton

RT-PCR:

real time – polymerase chain reaction

sHSP:

small heat shock proteins

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Acknowledgements

PCS acknowledges a faculty research grant and RV acknowledges short term research fellowship of Guru Gobind Singh Indraprastha University, Delhi.

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  1. University School of Biotechnology, Guru Gobind Singh Indraprastha University, New Delhi, India

    Prakash Chand Sharma & Renu Verma

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  1. Prakash Chand Sharma
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  1. Department of Medicine and Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Punit Kaur

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Sharma, P.C., Verma, R. (2018). Implication of HSP70 in the Pathogenesis of Gastric Cancer. In: Asea, A., Kaur, P. (eds) HSP70 in Human Diseases and Disorders. Heat Shock Proteins, vol 14. Springer, Cham. https://doi.org/10.1007/978-3-319-89551-2_6

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