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Clinical Implication of Heat Shock Protein 70 in Kidney Disease

Kidney Diseases and HSP70

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HSP70 in Human Diseases and Disorders

Part of the book series: Heat Shock Proteins ((HESP,volume 14))

Abstract

Heat shock protein (HSP) 70 has been investigated from various aspects in experimental studies, since it is the most abundant form of HSP in cells. HSP 70 is involved in response to various acute and chronic insults of kidney and also other parts of the urinary tract. Although it is not a specific biomarker for any of the kidney diseases, HSP 70 level of body fluids may be beneficial as a biomarker in some specific circumstances, for example for the differential diagnosis of “a children with fever”. The number of possible diseases in this situation is limited and an infection is most likely to be the reason of fever. Additionally, clarifying the exact role of HSP 70 in different kidney diseases enables to discover new therapeutic options in order to prevent renal fibrosis and chronic renal failure in the future. This chapter reviews experimental and clinical studies to find out the opportunities to utilize HSP 70 in daily clinical practice.

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Abbreviations

AGEs:

advanced glycosylated-end products

AKI:

acute kidney injury

AUC:

area under the curve

CKD:

chronic kidney disease

CSF:

cerebrospinal fluid

EMT:

epithelial-mesenchymal transition

ESRD:

end stage renal disease

GGA:

geranylgeranylacetone

HSP:

heat shock protein

IFNγ:

interferon gamma

IL-18:

interleukin 18

INS:

idiopathic nephrotic syndrome

JAK/STAT:

janus kinase/signal transducers and activators of transcription

KIM-1:

kidney injury molecule type 1

MEK/ERK:

Mitogen-activated protein kinase/ERK kinase/extracellular-signal-regulated kinase

NGAL:

neutrophil gelatinase-associated lipocalin

NF-kB:

nuclear factor kappa B

NOS:

nitric oxide synthase

p-STAT3:

phospho-signal transducer and activator of transcription 3

ROS:

reactive oxygen species

SLK:

Ste20-like kinase

STAT3:

Signal transducer and activator of transcription 3

TGF-β:

transforming growth factor beta

T1DM:

type 1 diabetes mellitus

uHSP70:

urine level of heat shock proetin 70

uHSP/Cr:

urine heat shock protein/creatinine ratio

UTI:

urinary tract infection

WT1:

wilms tumor 1

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Authors and Affiliations

  1. Istanbul Faculty of Medicine, Pediatric Nephrology Department, Istanbul University, Fatih, Istanbul, Turkey

    Alev Yilmaz & Zeynep Nagehan Yuruk Yildirim

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  1. Department of Medicine and Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Punit Kaur

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Yilmaz, A., Yildirim, Z.N.Y. (2018). Clinical Implication of Heat Shock Protein 70 in Kidney Disease. In: Asea, A., Kaur, P. (eds) HSP70 in Human Diseases and Disorders. Heat Shock Proteins, vol 14. Springer, Cham. https://doi.org/10.1007/978-3-319-89551-2_12

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