Abstract
A 56-year-old male patient with multiple nodules in both thyroid lobes underwent a left lobectomy due to a nodule with a 3.5 cm diameter in the left thyroid lobe. Histopathological examination of the surgical specimen revealed a minimally invasive follicular thyroid carcinoma (MI-FTC) without vascular invasion. After completion thyroidectomy, additional tumor foci were not detected in the right lobe. The patient received radioiodine ablation treatment (RAT) with 3700 MBq (100 mCi) iodine-131 (131I) 2 months after the operation. During the RAT, the serum thyroid-stimulating hormone (TSH) and thyroglobulin (Tg) levels were measured as 30 IU/ml and 19.5 ng/mL, respectively. Six months after the RAT, a diagnostic whole-body scintigraphy with 185 MBq 131I was performed to evaluate the ablation success. The serum-stimulated Tg level was <0.1 ng/mL, and a 131I whole-body scintigraphy was normal. The patient was followed up with neck USGs, serum suppressed and/or stimulated Tg levels, and/or 131I diagnostic whole-body scintigraphies for 10 years. The patient exhibited no clinical evidence of disease at the final follow-up.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Davies L, Welch HG. Current thyroid cancer trends in the United States. JAMA Otolaryngol Head Neck Surg. 2014;140:317–22.
Chow SM, Law SC, Mendenhall SK, Au SK, Yau S, Yuen KT, et al. Follicular thyroid carcinoma: prognostic factors and the role of radioiodine. Cancer. 2002;95:488–98.
Schlumberger M, Pacini F, Tuttle RM. Thyroid tumors. Pathology of thyroid tumors. Chapter 2. 4th ed. 2015. p. 41–55.
Goldstein NS, Czako P, Neill JS. Metastatic minimally invasive (encapsulated) follicular and Hurthle cell thyroid carcinoma: a study of 34 patients. Mol Pathol. 2000;13:123–30.
O’Neill CJ, Vaughan L, Learoyd DL, Sidhu SB, Delbridge LW, Sywak MS. Management of follicular thyroid carcinoma should be individualized based on degree of capsular and vascular invasion. Eur J Surg Oncol. 2011;37:181–5.
van Heerden JA, Hay ID, Goellner JR, Salomao D, Ebersold JR, Bergstralh EJ, et al. Follicular thyroid carcinoma with capsular invasion alone: a nonthreatening malignancy. Surgery. 1992;112:1130–6.
Sugino K, Ito K, Nagahama M, Kitagawa W, Shibuya H, Ohkuwa K, et al. Prognosis and prognostic factors for distant metastases and tumor mortality in follicular thyroid carcinoma. Thyroid. 2011;21(7):751.
Huang CC, Hsueh C, Liu FH, Chao TC, Lin JD. Diagnostic and therapeutic strategies for minimally and widely invasive follicular thyroid carcinomas. Surg Oncol. 2011;20:1–6.
Lang W, Choritz H, Hundeshagen H. Risk factors in follicular thyroid carcinomas. A retrospective follow-up study covering a 14-year period with emphasis on morphological findings. Am J Surg Pathol. 1986;10:246–55.
D’Avanzo A, Treseler P, Ituarte PH, Wong M, Streja L, Greenspan FS, et al. Follicular thyroid carcinoma: histology and prognosis. Cancer. 2004;100:1123–9.
Stenson G, Nilsson IL, Mu N, Larsson C, Lundgren CI, Juhlin CC, et al. Minimally invasive follicular thyroid carcinomas: prognostic factors. Endocrine. 2016;53:505–11.
Ban EJ, Andrabi A, Grodski S, Yeung M, Mclean C, Serpell J. Follicular thyroid cancer: minimally invasive tumors can give rise to metastases. ANZ J Surg. 2012;82:136–9.
Sugino K, Kameyama K, Ito K, Nagahama M, Kitagawa W, Shibuya H, et al. Outcomes and prognostic factors of 251 patients with minimally invasive follicular thyroid carcinoma. Thyroid. 2012;22(8):22798–804.
De Crea C, Raffaell M, Sessa L, Ronti S, Fadda G, Bellantone C, et al. Actual incidence and clinical behaviour of follicular thyroid carcinoma: an institutional experience. Sci World J. 2014. https://doi.org/10.1155/2014/952095.
Dionigi G, Kraimps JL, Schmid KW, Hermann M, Sheu-Grabellus SY, De Wailly P, et al. Minimally invasive follicular thyroid cancer (MIFTC)-a consensus report of the European Society of Endocrine Surgeons (ESES). Langenbeck’s Arch Surg. 2014;399:165–84.
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, et al. American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer. The American Thyroid Association Guidelines Task Force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2015;26:1–133.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Özkan, E., Soydal, Ç. (2019). Minimally Invasive Follicular Carcinoma. In: Özülker, T., Adaş, M., Günay, S. (eds) Thyroid and Parathyroid Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-78476-2_49
Download citation
DOI: https://doi.org/10.1007/978-3-319-78476-2_49
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-78475-5
Online ISBN: 978-3-319-78476-2
eBook Packages: MedicineMedicine (R0)