Abstract
This chapter provides incidence data on spontaneous ophthalmic abnormalities in the most commonly used species in toxicological and pharmacokinetic drug research. This data can be used to better differentiate test article-related ocular findings from background incidental lesions to enhance interpretation of ophthalmic findings, improve speed of drug development, reduce the number of studies that need to be repeated, and thus reduce the overall number of animals used in toxicology research and drug development.
Endorsed by the American College of Veterinary Ophthalmologists (ACVO).
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Acknowledgments
The authors thank the following contract research organizations and individuals for assistance in collection of the data for this chapter:
Charles River Laboratories, Wil Research, Ashland, Ohio. Robert Wally, Brian Ronk and Jeanette Howell
Charles River Laboratories, Reno, Nevada. Dr. Margaret Collins
Charles River Laboratories, Horsham, Pennsylvania. Dr. Douglas Learn
Envigo, East Millstone, New Jersey. Christopher Blum
MPI Research, Mattawan, Michigan
Powered Research, Research Triangle Park, North Carolina. Dr. David Culp, Justin Prater
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Gilger, B.C., Brown, M.H., Munger, R.J., Bartoe, J.T., Bussieres, M., Cook, C.S. (2018). Spontaneous Incidence of Ocular Abnormalities in Laboratory Animals. In: Gilger, B., Cook, C., Brown, M. (eds) Standards for Ocular Toxicology and Inflammation. Springer, Cham. https://doi.org/10.1007/978-3-319-78364-2_4
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