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Transfusion Management of the Obstetrical Patient pp 81–90Cite as

Von Willebrand Disease in Pregnancy

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Abstract

Von Willebrand disease is the most common bleeding disorder in women. There are three major types—type 1 with low levels of Von Willebrand factor (VWF), type 2 with abnormal VWF, and type 3 with no detectible WVF. Laboratory testing consists of checking factor VIII, VWF antigen, and VWF activity. Much controversy exists over diagnosis of VWD especially in patients with only moderately low levels. Treatment varies by disease type but ranges from desmopressin to use of VWF concentrates. An important feature of VWD in women is that estrogen administration can raise levels.

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Further Reading

  1. DeLoughery TG. Von Willebrand disease. Chapter 5. In:Hemostasis and thrombosis (Vademecum). 2nd ed. Switzerland: Springer; 2003. p. 37–42.

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  2. DeLoughery TG. Bleeding and thrombosis: Women’s issues. In: TD DL, editor. Hemostasis and thrombosis. Switzerland: Springer; 2015. p. 51–5.

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  6. Pacheco LD, Costantine MM, Saade GR, Mucowski S, Hankins GD, Sciscione AC. von Willebrand disease and pregnancy: a practical approach for the diagnosis and treatment. Am J Obstet Gynecol. 2010;203(3):194–200.

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Author information

Authors and Affiliations

  1. Oregon Health & Science University, Portland, OR, USA

    Thomas G. DeLoughery M.D., M.A.C.P., F.A.W.M.

Authors
  1. Thomas G. DeLoughery M.D., M.A.C.P., F.A.W.M.
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Corresponding author

Correspondence to Thomas G. DeLoughery M.D., M.A.C.P., F.A.W.M. .

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Editors and Affiliations

  1. University of Washington Medical Center, Bloodworks Northwest, Seattle, Washington, USA

    Theresa Nester

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DeLoughery, T.G. (2018). Von Willebrand Disease in Pregnancy. In: Nester, T. (eds) Transfusion Management of the Obstetrical Patient. Springer, Cham. https://doi.org/10.1007/978-3-319-77140-3_9

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  • DOI: https://doi.org/10.1007/978-3-319-77140-3_9

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-77139-7

  • Online ISBN: 978-3-319-77140-3

  • eBook Packages: MedicineMedicine (R0)

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